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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(1A) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd1
Synonym	D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	P18901
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL265
IUPHAR	214
DrugBank	N/A

Ligand

Name	DIHYDREXIDINE
Molecular formula	C17H17NO2
IUPAC name	5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
Molecular weight	267.328
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	2.5
Synonyms	AC1Q7A2Z 137417-08-4 Benzo(a)phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, trans- LS-186899 CHEMBL101446 PDSP2_000568 BDBM50049047 Dihydrexidine, DHX 5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol BRD-A99164655-003-01-5 LS-187553 AC1L1TV8 D0D3VT SCHEMBL4614578 10,11-Dihydroxyhexahydrobenzo(a)phenanthridine Benzo(a)phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, (6aR,12bS)-rel- L000828 5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol CHEBI:91996 PDSP1_000570 [ Show all ]
Inchi Key	BGOQGUHWXBGXJW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2
PubChem CID	60759
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50049047
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2.2 nM	PMID12628671	BindingDB
Ki	2.3 nM	PMID15492773	BindingDB
Ki	4.59 nM	PMID15492773	BindingDB
Ki	5.5 nM	PMID12628671	BindingDB
Ki	6.2 nM	PMID12628671, PMID15492773	BindingDB
Ki	9.7 nM	PMID15492773	BindingDB
Ki	10.0 nM	PMID15492773	BindingDB
Ki	34.0 nM	PMID12628671	BindingDB
Ki	100.0 nM	PMID12628671	BindingDB

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