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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	CHEMBL1484167
Molecular formula	C26H29BrN2OS
IUPAC name	2-[4-[(E)-(3-benzyl-1,3-benzothiazol-2-ylidene)methyl]-2,6-dimethylpyridin-1-ium-1-yl]butan-1-ol;bromide
Molecular weight	497.495
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	None
Synonyms	N/A
Inchi Key	CXKXKMJRASFHPW-UHFFFAOYSA-M
Inchi ID	InChI=1S/C26H29N2OS.BrH/c1-4-23(18-29)28-19(2)14-22(15-20(28)3)16-26-27(17-21-10-6-5-7-11-21)24-12-8-9-13-25(24)30-26;/h5-16,23,29H,4,17-18H2,1-3H3;1H/q+1;/p-1
PubChem CID	90660459
ChEMBL	CHEMBL1484167
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	3264.3 nM	PubChem BioAssay data set	ChEMBL
Potency	20596.2 nM	PubChem BioAssay data set	ChEMBL

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