Detailed GPCR-I-TASSER Statistics for O43194

Submitted Sequence

>sp|O43194|GPR39_HUMAN
MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQK
KGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSY
ATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPL
VNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAF
MCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQ
IRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLC
CRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQ
SKSQSLSLESLEPNSGAKPANSAAENGFQEHEV

Predicted Secondary Structure

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |             
Sequence MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
Prediction CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score 999999998877777777788666632999999999999999989977755058999922899982878999999999999999999999999996689878887927179999999999999999999998682300206386341388888864799999999999999986067413456655564235666534566777752798515737889999987764344689999999999999999998526667777752000046778888778899989999999999968999999999965434578126899999999999999999999899999759999999999848767887767666756767787888874556766678877876777767767766656778888777766778789999999777786554779

Predicted Solvent Accessibility

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |             
Sequence MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
Prediction 761442333332232333313313101001000000001001102310200010000001244021000030013121210001011201000001332000011000100000010000000102000000021000100102321233000000000001000001100000002233232443332223331233333242210000121233221210000011331113000000000000001022334434454444434444344434311100000000000000002110010000000334324310110000010100110020000000000000530040013000011324434444433443433433333332323334444344443442414234454565644543436334444644345333433335348

Predicted Normalized B-Factor


Read more about predicted normalized B-factor

  Top 10 Templates Used by GPCR-I-TASSER


Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |             
Sec.Str
Seq		CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
14n6hA 0.20 0.18 0.66 2.41Download -----------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVR---YTKMKTATNIYIFNLALADALATSTLPFQSAKYLM--TWPF--GELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD-------------------------GAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS------------KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD----PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------------------------------
24xeeA 0.25 0.28 0.87 3.56Download ---------------GPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLA-------RKSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTHPGG--------------------LVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVP-----------------GRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYASSAINPILYNLVSANFRQVFLSTLNIFEMLRIDEG-LRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAV
35gliA 0.21 0.20 0.71 4.00Download -------------ISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLL---YIIYKNKCMRNGPNILIASLALGDLLHIVIAIPINVYKLLAEDWPF--GAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDY---------------------KGSYLRICLLHPVMQFYATAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRIDEGGGSGGDRTGTWDAYLNDHLKQRREVAKTVFCLVLVFALCWLPLHLARILKLTLYNQNDPNRLLSFLLVLDYIGINMASLNSCANPIALYLVSKRFKNAFKSALCC--------------------------------------------------------------------------------------------
44xeeA 0.28 0.28 0.87 2.15Download -----GPNSDLDVNTD----------IYSKVLVTAIYLALFVVGTVGNSVTLFTL-------ARKSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTHPGG-------------------LVCTPIVDTATVKVVIQVNTFMS-FLFPMLVISILNTVIANKLTVMVP-----------------GRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYASSAINPILYNLVSANFRQVFLSTLNIFRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVMGETGV
54n6hA 0.20 0.18 0.67 3.14Download -----------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRY---TKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWP--FGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD------GAVVCMLQFPS-----------------PSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLS------------GSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDP----LVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------------------------------
62ziy 0.18 0.21 0.81 1.55Download LRDNETWWYNPSI-IVHPHWEFDQVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTKTKS---LQTPANMFIINLAFSDFTFSLVNFPLMTISCF--LKKWIFGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGAYTLE------------------------GVLCNCSFDYIDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPLEWV-------TPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCCQFDDKETE-DDKDAETE------IPAGESSDAAP--------------------------SADAAQMKE------------------
74djh 0.21 0.21 0.66 1.17Download -------------------------SPAIPVIITAVYSVVFVVGLVGNSLVMFVI---IRYTKMKTATNIYIFNLALADALVT-TTMPFQSTVYLMNSWPFG--DVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVRED-----------------------VDVIECSLQFPDDWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGNINTNGVKQTPNYREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSA----A------LSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP--------------------------------------------------------------------------------------------
84n6hA 0.20 0.18 0.66 2.94Download -------------------GARSASSLALAIAITALYSAVCAVGLLGNVLVMFG---IVRYTKMKTATNIYIFNLALADALA-TSTLPFQSAKYLMETWP--FGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD-------------------------GAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLL------------SGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD----PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------------------------------
93uon 0.16 0.21 0.65 1.76Download -----------------------------VVFIVLVAGSLSLVTIIGNILVMVSI---KVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYW--PLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVE---DGECYIQFF-----------------SNA--AV--TFGTAIAAFYLPVIIMTVLYWHISRASKSRINIFEGGHAANVTTGTWDAYPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPC--------IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLM---------------------------------------------------------------------------------------------
104n6hA 0.20 0.18 0.66 4.21Download ----------------GSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMF---GIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFG--ELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD-------------------------GAVVCMLQFPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS------------KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD----PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: MUSTER   2: SP3   3: FFAS-3D   4: cdPPAS   5: SPARKS-X   6: HHSEARCH2   7: HHSEARCH I   8: Neff-PPAS   9: HHSEARCH   10: pGenTHREADER   

  Top 5 Models Predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.75 (Read more about C-score)
  • Estimated TM-score = 0.62±0.14
  • Estimated RMSD = 8.8±4.6Å

  • Download Model 2
  • C-score = -1.16

  • Download Model 3
  • C-score = -1.61

  • Download Model 4
  • C-score = -3.92

  • Download Model 5
  • C-score = -4.33


    • [Click on O43194_results.tar.bz2 to download the tarball file including all modeling results listed on this page]