| Swiss ID: adrb2_human |
| Protein Name: Beta-2 adrenergic receptor (Beta-2 adrenoceptor) ( |
| Organism: Homo sapiens (Human). |
| Seqeunce Length: 413 |
| MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSPGRNCSTNDSLL |
| Multiple Sequence Alignment |
| Experimental Restraints: |
| Contact Restraint: C77-C116 PMID of associated paper: 2159799 |
| Contact Restraint: A46-A76 PMID of associated paper: 2836950 |
| Contact Restraint: D113-D79 PMID of associated paper: 2836950 |
| Contact Restraint: D79-C116 PMID of associated paper: 2836950 |
| Contact Restraint: C116-C77 PMID of associated paper: 2836950 |
| Contact Restraint: G83-I112 PMID of associated paper: 2836950 |
| Contact Restraint: F108-F166 PMID of associated paper: 2836950 |
| Contact Restraint: S111-S161 PMID of associated paper: 2836950 |
| Contact Restraint: S161-S203 PMID of associated paper: 2836950 |
| Contact Restraint: T110-T164 PMID of associated paper: 2836950 |
| Contact Restraint: D113-N312 PMID of associated paper: 10535920 |
| : MSA PMID of associated paper: 0 |
| Orientation Restraint: D79 PMID of associated paper: 2831218 |
| Orientation Restraint: T164 PMID of associated paper: 7901205 |
| Orientation Restraint: C125 PMID of associated paper: 2159799 |
| Orientation Restraint: N322 PMID of associated paper: 7492540 |
| Orientation Restraint: L310 PMID of associated paper: 8576196 |
| Orientation Restraint: L311 PMID of associated paper: 8576196 |
| Orientation Restraint: S165 PMID of associated paper: 8799191 |
| Orientation Restraint: V307 PMID of associated paper: 9443940 |
| Orientation Restraint: I314 PMID of associated paper: 9443940 |
| Orientation Restraint: V317 PMID of associated paper: 9443940 |
| Orientation Restraint: L324 PMID of associated paper: 9443940 |
| Orientation Restraint: S204 PMID of associated paper: 9249239 |
| Orientation Restraint: D113 PMID of associated paper: 10535920 |
| Experimental Data: |
| Experimental Data: C327R PMID of associated paper: 2846532 |
| Experimental Data: C327S PMID of associated paper: 2542304 |
| Experimental Data: D79N PMID of associated paper: 2831218 |
| Experimental Data: T164I PMID of associated paper: 7901205 |
| Experimental Data: C125V PMID of associated paper: 2159799 |
| Experimental Data: N322A PMID of associated paper: 7492540 |
| Experimental Data: N322D PMID of associated paper: 7492540 |
| Experimental Data: L310F PMID of associated paper: 8576196 |
| Experimental Data: L311F PMID of associated paper: 8576196 |
| Experimental Data: S165A PMID of associated paper: 8799191 |
| Experimental Data: R328 PMID of associated paper: 2824467 |
| Experimental Data: C327 PMID of associated paper: 2824467 |
| Experimental Data: E306 PMID of associated paper: 2824467 |
| Experimental Data: S329 PMID of associated paper: 2824467 |
| Experimental Data: I298 PMID of associated paper: 2824467 |
| Experimental Data: E306A PMID of associated paper: 9443940 |
| Experimental Data: V307A PMID of associated paper: 9443940 |
| Experimental Data: L310A PMID of associated paper: 9443940 |
| Experimental Data: L311A PMID of associated paper: 9443940 |
| Experimental Data: I314A PMID of associated paper: 9443940 |
| Experimental Data: V317A PMID of associated paper: 9443940 |
| Experimental Data: L324A PMID of associated paper: 9443940 |
| Experimental Data: A198 PMID of associated paper: 2836950 |
| Experimental Data: A200 PMID of associated paper: 2836950 |
| Experimental Data: Q170 PMID of associated paper: 2836950 |
| Experimental Data: Q197 PMID of associated paper: 2836950 |
| Experimental Data: G35 PMID of associated paper: 2836950 |
| Experimental Data: H172 PMID of associated paper: 2836950 |
| Experimental Data: H93 PMID of associated paper: 2836950 |
| Experimental Data: I94 PMID of associated paper: 2836950 |
| Experimental Data: L95 PMID of associated paper: 2836950 |
| Experimental Data: M171 PMID of associated paper: 2836950 |
| Experimental Data: W173 PMID of associated paper: 2836950 |
| Experimental Data: Y174 PMID of associated paper: 2836950 |
| Experimental Data: Y199 PMID of associated paper: 2836950 |
| Experimental Data: C125S PMID of associated paper: 9228019 |
| Experimental Data: S204S PMID of associated paper: 9249239 |
| Experimental Data: S204A PMID of associated paper: 9249239 |
| Experimental Data: H93A PMID of associated paper: 10535920 |
| Experimental Data: D113A PMID of associated paper: 10535920 |
| Experimental Data: D113C PMID of associated paper: 10535920 |
| Experimental Data: D113H PMID of associated paper: 10535920 |
| Experimental Data: S204C PMID of associated paper: 10617695 |
| Experimental Data: C77-C116 PMID of associated paper: 2159799 |
| Experimental Data: A46-A76 PMID of associated paper: 2836950 |
| Experimental Data: D113-D79 PMID of associated paper: 2836950 |
| Experimental Data: D79-C116 PMID of associated paper: 2836950 |
| Experimental Data: C116-C77 PMID of associated paper: 2836950 |
| Experimental Data: G83-I112 PMID of associated paper: 2836950 |
| Experimental Data: F108-F166 PMID of associated paper: 2836950 |
| Experimental Data: S111-S161 PMID of associated paper: 2836950 |
| Experimental Data: S161-S203 PMID of associated paper: 2836950 |
| Experimental Data: T110-T164 PMID of associated paper: 2836950 |
| Experimental Data: D113-N312 PMID of associated paper: 10535920 |
| Experimental Data: C77S PMID of associated paper: 2542304 |
| Experimental Data: C285S PMID of associated paper: 2542304 |
| Experimental Data: D79N PMID of associated paper: 2831218 |
| Experimental Data: T164I PMID of associated paper: 7901205 |
| Experimental Data: N312F PMID of associated paper: 8101966 |
| Experimental Data: N312A PMID of associated paper: 8101966 |
| Experimental Data: N312T PMID of associated paper: 8101966 |
| Experimental Data: N312Q PMID of associated paper: 8101966 |
| Experimental Data: Y326A PMID of associated paper: 7507928 |
| Experimental Data: C77V PMID of associated paper: 2159799 |
| Experimental Data: C116V PMID of associated paper: 2159799 |
| Experimental Data: C125V PMID of associated paper: 2159799 |
| Experimental Data: C285V PMID of associated paper: 2159799 |
| Experimental Data: N322A PMID of associated paper: 7492540 |
| Experimental Data: N322D PMID of associated paper: 7492540 |
| Experimental Data: P323A PMID of associated paper: 7492540 |
| Experimental Data: Y326F PMID of associated paper: 7492540 |
| Experimental Data: L310F PMID of associated paper: 8576196 |
| Experimental Data: L311F PMID of associated paper: 8576196 |
| Experimental Data: N293L PMID of associated paper: 8799191 |
| Experimental Data: S165A PMID of associated paper: 8799191 |
| Experimental Data: N312 PMID of associated paper: 2824467 |
| Experimental Data: N318 PMID of associated paper: 2824467 |
| Experimental Data: N322 PMID of associated paper: 2824467 |
| Experimental Data: G315 PMID of associated paper: 2824467 |
| Experimental Data: G320 PMID of associated paper: 2824467 |
| Experimental Data: I309 PMID of associated paper: 2824467 |
| Experimental Data: I314 PMID of associated paper: 2824467 |
| Experimental Data: I325 PMID of associated paper: 2824467 |
| Experimental Data: L310 PMID of associated paper: 2824467 |
| Experimental Data: L311 PMID of associated paper: 2824467 |
| Experimental Data: L324 PMID of associated paper: 2824467 |
| Experimental Data: F321 PMID of associated paper: 2824467 |
| Experimental Data: P323 PMID of associated paper: 2824467 |
| Experimental Data: S319 PMID of associated paper: 2824467 |
| Experimental Data: W313 PMID of associated paper: 2824467 |
| Experimental Data: Y308 PMID of associated paper: 2824467 |
| Experimental Data: Y316 PMID of associated paper: 2824467 |
| Experimental Data: Y326 PMID of associated paper: 2824467 |
| Experimental Data: V307 PMID of associated paper: 2824467 |
| Experimental Data: V317 PMID of associated paper: 2824467 |
| Experimental Data: N293 PMID of associated paper: 2824467 |
| Experimental Data: C285 PMID of associated paper: 2824467 |
| Experimental Data: G276 PMID of associated paper: 2824467 |
| Experimental Data: G280 PMID of associated paper: 2824467 |
| Experimental Data: H296 PMID of associated paper: 2824467 |
| Experimental Data: I277 PMID of associated paper: 2824467 |
| Experimental Data: I278 PMID of associated paper: 2824467 |
| Experimental Data: I291 PMID of associated paper: 2824467 |
| Experimental Data: I294 PMID of associated paper: 2824467 |
| Experimental Data: L275 PMID of associated paper: 2824467 |
| Experimental Data: L284 PMID of associated paper: 2824467 |
| Experimental Data: L287 PMID of associated paper: 2824467 |
| Experimental Data: M279 PMID of associated paper: 2824467 |
| Experimental Data: F282 PMID of associated paper: 2824467 |
| Experimental Data: F289 PMID of associated paper: 2824467 |
| Experimental Data: F290 PMID of associated paper: 2824467 |
| Experimental Data: P288 PMID of associated paper: 2824467 |
| Experimental Data: T281 PMID of associated paper: 2824467 |
| Experimental Data: T283 PMID of associated paper: 2824467 |
| Experimental Data: W286 PMID of associated paper: 2824467 |
| Experimental Data: V292 PMID of associated paper: 2824467 |
| Experimental Data: V295 PMID of associated paper: 2824467 |
| Experimental Data: V297 PMID of associated paper: 2824467 |
| Experimental Data: Y219 PMID of associated paper: 7565630 |
| Experimental Data: I72 PMID of associated paper: 9443940 |
| Experimental Data: V307A PMID of associated paper: 9443940 |
| Experimental Data: Y308A PMID of associated paper: 9443940 |
| Experimental Data: I309A PMID of associated paper: 9443940 |
| Experimental Data: L310A PMID of associated paper: 9443940 |
| Experimental Data: L311A PMID of associated paper: 9443940 |
| Experimental Data: I314A PMID of associated paper: 9443940 |
| Experimental Data: V317A PMID of associated paper: 9443940 |
| Experimental Data: G320A PMID of associated paper: 9443940 |
| Experimental Data: L324A PMID of associated paper: 9443940 |
| Experimental Data: A119 PMID of associated paper: 2836950 |
| Experimental Data: A128 PMID of associated paper: 2836950 |
| Experimental Data: A202 PMID of associated paper: 2836950 |
| Experimental Data: A46 PMID of associated paper: 2836950 |
| Experimental Data: A57 PMID of associated paper: 2836950 |
| Experimental Data: A76 PMID of associated paper: 2836950 |
| Experimental Data: A78 PMID of associated paper: 2836950 |
| Experimental Data: A85 PMID of associated paper: 2836950 |
| Experimental Data: A91 PMID of associated paper: 2836950 |
| Experimental Data: A92 PMID of associated paper: 2836950 |
| Experimental Data: R151 PMID of associated paper: 2836950 |
| Experimental Data: N51 PMID of associated paper: 2836950 |
| Experimental Data: D113 PMID of associated paper: 2836950 |
| Experimental Data: D79 PMID of associated paper: 2836950 |
| Experimental Data: C116 PMID of associated paper: 2836950 |
| Experimental Data: C125 PMID of associated paper: 2836950 |
| Experimental Data: C77 PMID of associated paper: 2836950 |
| Experimental Data: E107 PMID of associated paper: 2836950 |
| Experimental Data: E122 PMID of associated paper: 2836950 |
| Experimental Data: G162 PMID of associated paper: 2836950 |
| Experimental Data: G37 PMID of associated paper: 2836950 |
| Experimental Data: G50 PMID of associated paper: 2836950 |
| Experimental Data: G83 PMID of associated paper: 2836950 |
| Experimental Data: G90 PMID of associated paper: 2836950 |
| Experimental Data: I112 PMID of associated paper: 2836950 |
| Experimental Data: I121 PMID of associated paper: 2836950 |
| Experimental Data: I127 PMID of associated paper: 2836950 |
| Experimental Data: I153 PMID of associated paper: 2836950 |
| Experimental Data: I154 PMID of associated paper: 2836950 |
| Experimental Data: I159 PMID of associated paper: 2836950 |
| Experimental Data: I169 PMID of associated paper: 2836950 |
| Experimental Data: I201 PMID of associated paper: 2836950 |
| Experimental Data: I205 PMID of associated paper: 2836950 |
| Experimental Data: I214 PMID of associated paper: 2836950 |
| Experimental Data: I38 PMID of associated paper: 2836950 |
| Experimental Data: I43 PMID of associated paper: 2836950 |
| Experimental Data: I47 PMID of associated paper: 2836950 |
| Experimental Data: I55 PMID of associated paper: 2836950 |
| Experimental Data: I58 PMID of associated paper: 2836950 |
| Experimental Data: L115 PMID of associated paper: 2836950 |
| Experimental Data: L124 PMID of associated paper: 2836950 |
| Experimental Data: L155 PMID of associated paper: 2836950 |
| Experimental Data: L163 PMID of associated paper: 2836950 |
| Experimental Data: L167 PMID of associated paper: 2836950 |
| Experimental Data: L212 PMID of associated paper: 2836950 |
| Experimental Data: L42 PMID of associated paper: 2836950 |
| Experimental Data: L45 PMID of associated paper: 2836950 |
| Experimental Data: L53 PMID of associated paper: 2836950 |
| Experimental Data: L75 PMID of associated paper: 2836950 |
| Experimental Data: L80 PMID of associated paper: 2836950 |
| Experimental Data: L84 PMID of associated paper: 2836950 |
| Experimental Data: M156 PMID of associated paper: 2836950 |
| Experimental Data: M215 PMID of associated paper: 2836950 |
| Experimental Data: M36 PMID of associated paper: 2836950 |
| Experimental Data: M40 PMID of associated paper: 2836950 |
| Experimental Data: M82 PMID of associated paper: 2836950 |
| Experimental Data: F108 PMID of associated paper: 2836950 |
| Experimental Data: F166 PMID of associated paper: 2836950 |
| Experimental Data: F208 PMID of associated paper: 2836950 |
| Experimental Data: F217 PMID of associated paper: 2836950 |
| Experimental Data: F49 PMID of associated paper: 2836950 |
| Experimental Data: F89 PMID of associated paper: 2836950 |
| Experimental Data: P168 PMID of associated paper: 2836950 |
| Experimental Data: P211 PMID of associated paper: 2836950 |
| Experimental Data: P88 PMID of associated paper: 2836950 |
| Experimental Data: S111 PMID of associated paper: 2836950 |
| Experimental Data: S120 PMID of associated paper: 2836950 |
| Experimental Data: S161 PMID of associated paper: 2836950 |
| Experimental Data: S165 PMID of associated paper: 2836950 |
| Experimental Data: S203 PMID of associated paper: 2836950 |
| Experimental Data: S204 PMID of associated paper: 2836950 |
| Experimental Data: S207 PMID of associated paper: 2836950 |
| Experimental Data: S220 PMID of associated paper: 2836950 |
| Experimental Data: S41 PMID of associated paper: 2836950 |
| Experimental Data: S74 PMID of associated paper: 2836950 |
| Experimental Data: T110 PMID of associated paper: 2836950 |
| Experimental Data: T118 PMID of associated paper: 2836950 |
| Experimental Data: T123 PMID of associated paper: 2836950 |
| Experimental Data: T164 PMID of associated paper: 2836950 |
| Experimental Data: T56 PMID of associated paper: 2836950 |
| Experimental Data: T73 PMID of associated paper: 2836950 |
| Experimental Data: W109 PMID of associated paper: 2836950 |
| Experimental Data: W158 PMID of associated paper: 2836950 |
| Experimental Data: Y209 PMID of associated paper: 2836950 |
| Experimental Data: V114 PMID of associated paper: 2836950 |
| Experimental Data: V117 PMID of associated paper: 2836950 |
| Experimental Data: V126 PMID of associated paper: 2836950 |
| Experimental Data: V129 PMID of associated paper: 2836950 |
| Experimental Data: V152 PMID of associated paper: 2836950 |
| Experimental Data: V157 PMID of associated paper: 2836950 |
| Experimental Data: V160 PMID of associated paper: 2836950 |
| Experimental Data: V206 PMID of associated paper: 2836950 |
| Experimental Data: V210 PMID of associated paper: 2836950 |
| Experimental Data: V213 PMID of associated paper: 2836950 |
| Experimental Data: V216 PMID of associated paper: 2836950 |
| Experimental Data: V218 PMID of associated paper: 2836950 |
| Experimental Data: V39 PMID of associated paper: 2836950 |
| Experimental Data: V44 PMID of associated paper: 2836950 |
| Experimental Data: V48 PMID of associated paper: 2836950 |
| Experimental Data: V52 PMID of associated paper: 2836950 |
| Experimental Data: V54 PMID of associated paper: 2836950 |
| Experimental Data: V81 PMID of associated paper: 2836950 |
| Experimental Data: V86 PMID of associated paper: 2836950 |
| Experimental Data: V87 PMID of associated paper: 2836950 |
| Experimental Data: C116R PMID of associated paper: 9228019 |
| Experimental Data: C125S PMID of associated paper: 9228019 |
| Experimental Data: S204S PMID of associated paper: 9249239 |
| Experimental Data: S207S PMID of associated paper: 9249239 |
| Experimental Data: S204A PMID of associated paper: 9249239 |
| Experimental Data: S207A PMID of associated paper: 9249239 |
| Experimental Data: C116F PMID of associated paper: 9452461 |
| Experimental Data: N312C PMID of associated paper: 10535920 |
| Experimental Data: H296A PMID of associated paper: 10535920 |
| Experimental Data: D113A PMID of associated paper: 10535920 |
| Experimental Data: D113C PMID of associated paper: 10535920 |
| Experimental Data: D113H PMID of associated paper: 10535920 |
| Experimental Data: N312H PMID of associated paper: 10535920 |
| Experimental Data: E122A PMID of associated paper: 10652295 |
| Experimental Data: S204C PMID of associated paper: 10617695 |
| Experimental Data: S207C PMID of associated paper: 10617695 |
| Experimental Data: S203A PMID of associated paper: 10964911 |
| Experimental Data: S203T PMID of associated paper: 10964911 |
| Experimental Data: S203V PMID of associated paper: 10964911 |
| Experimental Data: S203C PMID of associated paper: 10964911 |
| Experimental Data: MSA PMID of associated paper: 0 |
| GPCR Related Corss-reference Links: |
| GPCRDB GPCR-OKB UniProt_P07550 |