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I-TASSER QUARK LOMETS COACH COFACTOR MUSTER SEGMER FG-MD ModRefiner REMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom EvoDesign GPCR-I-TASSER

TM-score TM-align MMalign NWalign EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW CASP7 CASP8 CASP9 CASP10 CASP11


(The server completed predictions for 205635 proteins submitted by 51451 users from 116 countries)
(The template library was updated on 2014/12/17)

I-TASSER server is an on-line platform for protein structure and function predictions. 3D models are built based on multiple-threading alignments by LOMETS and iterative template fragment assembly simulations; function inslights are derived by matching the 3D models with BioLiP protein function database. I-TASSER (as 'Zhang-Server') was ranked as the No 1 server for protein structure prediction in recent CASP7, CASP8, CASP9, and CASP10 experiments. It was also ranked as the best for function prediction in CASP9. The server is in active development with the goal to provide the most accurate structural and function predictions using state-of-the-art algorithms. The server is only for non-commercial use. Please report problems and questions at I-TASSER message board and some members will study and answer the questions asap. (>> More about the server ...)

Download I-TASSER Standalone Package (Version 4.2)

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Copy and paste your sequence here (<1,500 residues, in FASTA format):

Or upload the sequence from your local computer:

Email: (mandatory, where results will be sent to)

Password: (mandatory, please click here if you do not have a password)

ID: (optional, your given name of the protein)

Option I: Assign additional restraints & templates to guide I-TASSER modeling.

  • Assign contact/distance restraints
  • Atom-atom restraints Explanation
  • Specify template without alignment
  • Type a PDB ID Explanation
  • Specify template without alignment
  • Upload a structure Explanation
  • Specify template with alignment
  • Template & alignment Explanation

Option II: Exclude some templates from I-TASSER template library.

  • Exclude homologous templates
  • Type a cutoff (e.g. '60%') Explanation
  • Exclude specific template proteins
  • Upload a file listing all PDB IDs Explanation

Option III: Specify secondary structure for specific residues.


(Please submit a new job only after your old job is completed)


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