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I-TASSER QUARK LOMETS COACH COFACTOR MUSTER SEGMER FG-MD ModRefiner REMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom EvoDesign GPCR-I-TASSER

TM-score TM-align MMalign NWalign EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW CASP7 CASP8 CASP9 CASP10 CASP11


(The server completed predictions for 216871 proteins submitted by 54354 users from 117 countries)
(The template library was updated on 2015/03/02)

I-TASSER (Iterative Threading ASSEmbly Refinement) is an advanced computer algorithm for protein structure and function predictions. Structural templates are first identified from the PDB by the multiple-threading program LOMETS; full-length models are then constructed by iterative template fragment assembly simulations; function inslights of the target are finally derived by aligning the 3D models with the protein function database BioLiP. I-TASSER (as 'Zhang-Server') was ranked as the No 1 server for protein structure prediction in recent CASP7, CASP8, CASP9, CASP10, and CASP11 experiments. It was also ranked as the best for function prediction in CASP9. The server is in active development with the goal to provide the most accurate structural and function predictions using state-of-the-art algorithms. Please report problems and questions at I-TASSER message board and some members will study and answer the questions asap. (>> More about the server ...)

Download I-TASSER Standalone Package (Version 4.2)

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Copy and paste your sequence here (<1,500 residues, in FASTA format). Click here for a sample input:

Or upload the sequence from your local computer:

Email: (optional, where results will be sent to)

Password: (optional, please click here if you want to have a password to track your jobs)

ID: (optional, your given name of the protein)

Option I: Assign additional restraints & templates to guide I-TASSER modeling.

  • Assign contact/distance restraints
  • Atom-atom restraints Explanation
  • Specify template without alignment
  • Type a PDB ID Explanation
  • Specify template without alignment
  • Upload a structure Explanation
  • Specify template with alignment
  • Template & alignment Explanation

Option II: Exclude some templates from I-TASSER template library.

  • Exclude homologous templates
  • Type a cutoff (e.g. '60%') Explanation
  • Exclude specific template proteins
  • Upload a file listing all PDB IDs Explanation

Option III: Specify secondary structure for specific residues.


(Please submit a new job only after your old job is completed)
(If you need to submit multiple jobs, please go to DNAStar which implements I-TASSER through cloud computing)


I-TASSER News:
References:

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