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I-TASSER QUARK LOMETS COACH COFACTOR MUSTER SEGMER FG-MD ModRefiner REMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom EvoDesign GPCR-I-TASSER BindProf BindProfX ResQ IonCom STRUM

TM-score TM-align MMalign NWalign EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot I-TASSER-MR

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW HPSF CASP7 CASP8 CASP9 CASP10 CASP11 CASP12


(The server completed predictions for 316191 proteins submitted by 77829 users from 130 countries)
(The template library was updated on 2017/02/09)

I-TASSER (Iterative Threading ASSEmbly Refinement) is a hierarchical approach to protein structure and function prediction. Structural templates are first identified from the PDB by multiple threading approach LOMETS; full-length atomic models are then constructed by iterative template fragment assembly simulations. Finally, function insights of the target are derived by threading the 3D models through protein function database BioLiP. I-TASSER (as 'Zhang-Server') was ranked as the No 1 server for protein structure prediction in recent community-wide CASP7, CASP8, CASP9, CASP10, CASP11, and CASP12 experiments. It was also ranked as the best for function prediction in CASP9. The server is in active development with the goal to provide the most accurate structural and function predictions using state-of-the-art algorithms. Please report problems and questions at I-TASSER message board and our members will study and answer the questions asap. (>> More about the server ...)

Welcome to the 2017 I-TASSER Workshop (Greensboro, NC, March 15, 2017)

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