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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin D2 receptor
Species	Rattus norvegicus (Rat)
Gene	Ptgdr
Synonym	DP1 receptor PGD receptor PGD2 receptor DP1 prostaglandin D2 receptor (DP) Prostanoid DP receptor prostanoid DP receptor-like PTGDR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MNESYRCQAATWVERGSSATMGGVAFSAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNRSLKELLPASGNQLCEAFAFLMSFFGLASTLQLLAMALECWLSLGHPFFYQRHITARRGVLVAPVAGAFSLAFCALPFAGFGKFVQYCPGTWCFIQMIHKKRSFSVIGFSVLYSSLMALLVLATVVCNLGAMSNLYAMHRRQRHHPRRCSRDRAQSGSDYRHGSPNPLEELDHFVLLALTTVLFTMCSLPLIYRAYYGAFKLVDRADGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKTFTRPLIYRNWCSHSWQTNMESTL
UniProt	Q9R261
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	338
DrugBank	N/A

Ligand

Name	15(R)-Prostaglandin E1
Molecular formula	C20H34O5
IUPAC name	7-[(1R,2R,3R)-3-hydroxy-2-[(E,3R)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
Molecular weight	354.487
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	3.2
Synonyms	15-epi-PGE1 7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(R)-3-hydroxy-oct-1-enyl)-5-oxo-cyclopentyl]-heptanoic acid HMS3648D07 V2N896SN9V 15R-Prostaglandin E1 AC1NR1FD Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11alpha,13E,15R)- 15(R)-PGE1 7-((1R,2R,3R)-3-Hydroxy-2-((1E,3R)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoic acid SR-01000946408-1 15-Epiprostaglandin E1 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3R)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid J-013704 ZINC3830202 20897-91-0 Alprostadil impurity D [EP] SCHEMBL11786980 7-((1R,2R,3R)-3-hydroxy-2-((R,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoic acid CHEMBL62570 UNII-V2N896SN9V 15R-PGE1 9-oxo-11R,15R-dihydroxy-13E-prostaenoic acid LMFA03010055 1213AH BDBM50101828 SR-01000946408 [ Show all ]
Inchi Key	GMVPRGQOIOIIMI-CHCORRSHSA-N
Inchi ID	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16-,17-,19-/m1/s1
PubChem CID	5283056
ChEMBL	CHEMBL62570
IUPHAR	N/A
BindingDB	50101828
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3758.0 nM	PMID6292197	BindingDB

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