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GLASS

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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	Rimcazole
Molecular formula	C21H27N3
IUPAC name	9-[3-[(3R,5S)-3,5-dimethylpiperazin-1-yl]propyl]carbazole
Molecular weight	321.468
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.9
Synonyms	75859-04-0 9-[3-(3,5-cis-dimethylpiperazino)propyl]carbazole 9H-Carbazole, 9-(3-(3,5-dimethyl-1-piperazinyl)propyl)-, cis- BW-234U D0M9GE Rimcazole [INN] 9-[3-((3R,5R)-3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole 9-[3-(3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole(rimcazole) AC1Q29PL CHEBI:94713 LS-177217 SCHEMBL99084 9-[3-(3,5-cis-dimethylpiperazino)-propyl]-carbazole 9-[3-[(3S,5R)-3,5-dimethylpiperazin-1-yl]propyl]carbazole BDBM50019742 cis-9-(3-(3,5-dimethyl-1-piperazinyl)propyl)carbazole Rimcazol [INN-Spanish] ZINC22920326 9-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)propyl)-9H-carbazole 9-[3-(3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole AC1L1ETO C21H27N3 DTXSID7048162 Rimcazolum 9-[3-((3R,5S)-3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole 9-[3-(Cis-3,5-Dimethyl-1-Piperazinyl)Propyl]Carbazole Hydrochloride AOB5285 NCGC00025187-01 Tocris-1497 9-[3-(3,5-cis-dimethylpiperazino)propyl]-carbazole 9-{3-[(3R,5S)-3,5-dimethylpiperazin-1-yl]propyl}-9H-carbazole BW 234U cis-9-[3-(3,5-dimethyl-1-piperazinyl)propyl]carbazole 9-(3-(3,5-dimethylpiperazin-1-yl)propyl)-9H-carbazole 9-[3-(3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole (Rimcazole) (BW234U) AC1Q29PK C3N1PS8CX1 GUDVQJXODNJRIJ-CALCHBBNSA-N Rimcazolum [INN-Latin] 9-[3-((3S,5R)-3,5-Dimethyl-piperazin-1-yl)-propyl]-9H-carbazole 9-[3-[(3R,5S)-3,5-dimethylpiperazin-1-yl]propyl]carbazole API0009158 CHEMBL275707 Rimcazol UNII-C3N1PS8CX1 [ Show all ]
Inchi Key	GUDVQJXODNJRIJ-CALCHBBNSA-N
Inchi ID	InChI=1S/C21H27N3/c1-16-14-23(15-17(2)22-16)12-7-13-24-20-10-5-3-8-18(20)19-9-4-6-11-21(19)24/h3-6,8-11,16-17,22H,7,12-15H2,1-2H3/t16-,17+
PubChem CID	53389
ChEMBL	CHEMBL275707
IUPHAR	N/A
BindingDB	50019742
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<8000.0 nM	PMID11543687	BindingDB,ChEMBL

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