You can:
Name | Metabotropic glutamate receptor 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | GRM1 |
Synonym | SCAR13 MGLUR1 mGlu1 receptor metabotropic glutamate receptor 1 GPRC1A [ Show all ] |
Disease | Alzheimer disease; Huntington's disease Neurological disease Neuropathic pain Schizophrenia Pain |
Length | 1194 |
Amino acid sequence | MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL |
UniProt | Q13255 |
Protein Data Bank | 4or2, 3ks9 |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 4or2. |
BioLiP | BL0271871,BL0271876, BL0271872,BL0271873,BL0271874,, BL0174211,BL0174213, BL0174210,BL0174212 |
Therapeutic Target Database | T27137 |
ChEMBL | CHEMBL3772 |
IUPHAR | 289 |
DrugBank | BE0000824 |
Name | CHEMBL1098212 |
---|---|
Molecular formula | C16H9F3N2O3S2 |
IUPAC name | [2-cyano-4-(2-methyl-1,3-benzothiazol-5-yl)phenyl] trifluoromethanesulfonate |
Molecular weight | 398.374 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 0 |
XlogP | 4.9 |
Synonyms | 2-Cyano-4-(2-methylbenzo[d]thiazol-5-yl)phenyl trifluoromethanesulfonate BDBM50317843 |
Inchi Key | GXRHWBFQOVAGDT-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H9F3N2O3S2/c1-9-21-13-7-11(3-5-15(13)25-9)10-2-4-14(12(6-10)8-20)24-26(22,23)16(17,18)19/h2-7H,1H3 |
PubChem CID | 46888002 |
ChEMBL | CHEMBL1098212 |
IUPHAR | N/A |
BindingDB | 50317843 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Inhibition | >50.0 % | PMID20382541 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218