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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	UNII-8L7H229K4I
Molecular formula	C14H21NO
IUPAC name	3-[(3R)-1-propylpiperidin-3-yl]phenol
Molecular weight	219.328
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.0
Synonyms	(r)-3-(3-hydroxyphenyl)-N-propylpiperidine AC1L48LV Lopac0_000986 R-3-(3-Hydroxyphenyl)-N-propylpiperidine HCl 3-[(3R)-1-propylpiperidin-3-yl]phenol NCGC00162308-02 SR-01000075393-11 85976-54-1 Lopac-P-102 Preclamol, (R)- 3-((R)-1-Propyl-piperidin-3-yl)-phenol BDBM50010618 NCGC00015776-01 R-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride 3PPP,(-) CHEMBL7393 PDSP1_000628 (+)-3-(1-Propyl-piperidin-3-yl)-phenol 8L7H229K4I Lopac-P-103 R(+)-3-PPP 3-(1-Propyl-piperidin-3-yl)-phenol CCG-205066 NCGC00015776-02 SCHEMBL8354256 cid_202478 PDSP2_000624 ZINC393 [ Show all ]
Inchi Key	HTSNFXAICLXZMA-ZDUSSCGKSA-N
Inchi ID	InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m0/s1
PubChem CID	202478
ChEMBL	CHEMBL7393
IUPHAR	N/A
BindingDB	50010618
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	10000.0 nM	PubChem BioAssay data set	ChEMBL
Potency	15848.9 nM	PubChem BioAssay data set	ChEMBL
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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