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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMuscarinic acetylcholine receptor M1
SpeciesRattus norvegicus (Rat)
GeneChrm1
SynonymM1R
M1 receptor
Chrm-1
M1 muscarinic acetylcholine receptor
cholinergic receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProtP08482
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL276
IUPHAR13
DrugBankN/A

Known ligands

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Total entries: 2128
Page:  / 22 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
102D structureDAPHC20H15N3O2329.3594 / 33.8Yes
122D structureCHEMBL68482C15H25N3OS295.4455 / 03.7Yes
7162D structureCHEMBL308803C13H19N3O5S329.3719 / 2N/AN/A
10822D structureCHEMBL115710C28H36F2N2O3486.6047 / 04.2Yes
12152D structureCHEMBL339175C10H16N4192.2663 / 10.9Yes
13302D structureCHEMBL68292C29H40N6O3520.6786 / 22.5No
14152D structure1-(4-methylpiperazin-1-yl)-4-phenylphthalazineC19H20N4304.3974 / 03.0Yes
19712D structureRutaecarpineC18H13N3O287.3222 / 13.0Yes
29822D structureCHEMBL553066C17H23ClN2O3338.8324 / 3N/AN/A
30612D structureCHEMBL1773104C30H29N5O5S571.6528 / 14.1No
30952D structurePROPYLBENZILYLCHOLINE MUSTARDC21H26ClNO3375.8934 / 14.2Yes
32262D structureLopac-D-2763C34H41N5O8S679.7899 / 4N/ANo
5573772D structureSCHEMBL18211801C27H26FN3O3459.5215 / 23.8Yes
33942D structureCHEMBL1916222C22H31N3O3385.5084 / 02.7Yes
35912D structuretranylcypromineC9H11N133.1941 / 11.5Yes
36842D structureCHEMBL1202000C64H77N13O61124.4113 / 47.7No
37492D structureSodium valproateC8H15NaO2166.1962 / 0N/AN/A
45702D structureCHEMBL131587C16H25N3S291.4574 / 03.2Yes
46802D structureCHEMBL356373C17H24N4284.4074 / 13.1Yes
47352D structure1077-27-6C8H14O2S2206.3184 / 11.7Yes
47622D structureCHEMBL48366C14H13ClN2244.7222 / 03.1Yes
49612D structureCHEMBL103189C23H26N4OS406.5484 / 12.4Yes
55852D structureCHEMBL112528C28H29F2N3O2477.5566 / 14.6Yes
57942D structureCHEMBL292103C11H19NO2S229.3384 / 11.5Yes
62142D structureN-(2-aminoethyl)-4-chlorobenzamideC9H11ClN2O198.652 / 20.7Yes
63832D structureCHEMBL302604C24H31N7O3465.5587 / 3-1.2Yes
64122D structureCHEMBL68827C21H27N7O4S473.5529 / 3-1.9Yes
65892D structureCHEMBL442369C12H17N3O5S315.3449 / 2N/AN/A
66072D structurecarbacholC6H15ClN2O2182.6483 / 1N/AN/A
67382D structureMRS 1754C26H26N6O4486.5326 / 24.9Yes
69752D structureCHEMBL64067C20H21NO3323.3924 / 11.5Yes
70352D structureNCGC00015331-01C34H48N4+2512.7862 / 29.5No
71072D structureTocris-0591C38H42N4O6650.77610 / 44.0No
71352D structureCHEMBL446925C17H21Cl2N3OS386.3353 / 12.7Yes
72142D structureCHEMBL117193C16H25N3O275.3964 / 12.6Yes
74272D structureCHEMBL324518C29H32F2N2O462.5855 / 15.7No
76022D structureCarbetapentane citrateC26H39NO10525.59511 / 4N/ANo
76322D structureCHEMBL3298591C17H19N3O2S329.4185 / 13.1Yes
77192D structurebeta-NarcotineC22H23NO7413.4268 / 02.7Yes
79402D structureCHEMBL214923C23H25F2NO3401.4546 / 14.1Yes
81542D structureCHEMBL70154C30H42N6O3534.7056 / 23.0No
81942D structureNCGC00015135-01C16H18N2OS286.3933 / 23.0Yes
83682D structureCHEMBL63746C25H25NO7S483.5359 / 3N/AN/A
84742D structureCHEMBL543375C7H13ClN2O2192.6433 / 2N/AN/A
84792D structureCHEMBL126735C23H30N2334.5072 / 14.7Yes
85472D structureLopac-D-149C16H21NO3275.3484 / 00.0Yes
86162D structureCHEMBL353276C22H24N4O360.4615 / 13.5Yes
86182D structureNEOSTIGMINEC12H19N2O2+223.2962 / 01.5Yes
86812D structureCHEMBL540013C26H33NO2391.5553 / 05.8No
87102D structureCHEMBL545342C23H27Cl2NO404.3752 / 1N/AN/A
89172D structureCHEMBL42553C16H19Cl2NO2328.2333 / 03.9Yes
89712D structureCHEMBL158311C34H40N8O2S2656.8688 / 35.3No
104352D structureSB 204070 hydrochlorideC19H27ClN2O4382.8856 / 13.5Yes
106772D structureCHEMBL2021360C8H15NOS173.2743 / 01.1Yes
112532D structurecystamineC4H12N2S2152.2744 / 2-1.0Yes
113192D structureLopac-N-1771C40H43N3O6661.7998 / 53.2No
117082D structureDEXPROPRANOLOLC16H21NO2259.3493 / 23.0Yes
117952D structurecimetidineC10H16N6S252.344 / 30.4Yes
120782D structureLopac-G-120C17H17N3O2295.3425 / 23.3Yes
122822D structureCHEMBL540013C26H34ClNO2428.0133 / 1N/AN/A
124082D structureCHEMBL304042C21H23NO3337.4194 / 11.9Yes
124102D structureCHEMBL294345C21H23NO3337.4194 / 11.9Yes
4644312D structureCHEMBL3608417C24H24FN5O3449.4866 / 21.4Yes
129692D structure(S)-2-Amino-3-chloropropanoic acidC3H6ClNO2123.5363 / 2-2.8Yes
130682D structureBW 284c51C27H38N2O+2406.6141 / 05.2No
133242D structureQUISQUALIC ACIDC5H7N3O5189.1276 / 3-3.9Yes
135772D structureCHEMBL11497C29H30F3NO465.565 / 07.1No
136402D structureCHEMBL26998C16H25NO247.3822 / 14.1Yes
138632D structuredaphnetinC9H6O4178.1434 / 21.2Yes
139602D structurespermidineC7H19N3145.253 / 3-1.0Yes
141212D structureCHEMBL466851C15H8BrCl2NO2385.0382 / 04.3Yes
142302D structure180083-23-2C32H32N4O3520.6336 / 05.6No
147812D structureCHEMBL443334C16H12FNO3285.2744 / 02.5Yes
149102D structureNCGC00016051-01C13H8N4O3268.2327 / 40.2Yes
149172D structureLopac-P-8887C21H34O2318.5012 / 14.9Yes
150142D structureLopac-E-2375C29H40N2O4480.6496 / 14.7Yes
151062D structuredisulfiramC10H20N2S4296.5244 / 03.9Yes
152282D structureCHEMBL355350C19H26N4O326.4445 / 13.2Yes
152902D structureNCGC00015922-01C15H16N4O268.323 / 21.6Yes
154192D structureCHEMBL540310C15H19ClN4290.7954 / 1N/AN/A
157542D structurehydroxylamineH3NO33.032 / 2-1.2Yes
159352D structureMLS000536463C23H23ClN2O6458.8956 / 15.3No
160482D structureCHEMBL596509C21H12F4N2O3416.3328 / 04.6Yes
166802D structureNCGC00016004-01C8H9N3O2179.1793 / 1-0.1Yes
168272D structureCHEMBL168581C16H25NOS279.4423 / 04.1Yes
170562D structureCHEMBL321842C11H18N2O194.2783 / 01.2Yes
173832D structureCHEMBL1773096C21H18FN3O4S427.456 / 13.6Yes
175122D structureCHEMBL68160C15H25N3OS295.4455 / 03.7Yes
177182D structureCHEMBL504572C16H8F5NO3357.2368 / 03.8Yes
178892D structureBmy-7378C22H31N3O3385.5085 / 02.8Yes
185232D structureCHEMBL126332C15H25N3O2S311.4446 / 03.9Yes
186402D structureNCGC00017128-01C16H16N5NaO7S2477.44212 / 2N/ANo
188132D structuretcpobopC16H8Cl4N2O2402.0524 / 06.0No
188992D structureAC1LQZR1C27H30N4O426.5643 / 15.4No
191822D structureTocris-0871C5H10N2S130.2092 / 10.6Yes
193962D structureLopac-A-8598C9H11N3O4225.2045 / 3-2.4Yes
194612D structureCHEMBL76107C14H23N3OS281.4185 / 03.0Yes
195592D structureCHEMBL217456C27H33F2NO3457.5626 / 05.8No
197422D structureCHEMBL2112509C24H27F2NO3415.4816 / 04.5Yes
201672D structureimipramineC19H24N2280.4152 / 04.8Yes

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