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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H3 receptor
Species	Homo sapiens (Human)
Gene	HRH3
Synonym	HH3R H3R H3 receptor GPCR97 G-protein coupled receptor 97
Disease	Obese insulin-resistant disorders Excessive daytime sleepiness Sleep disorders Schizophrenia Pain Obesity Metabolic disorders Mild to moderate alzheimer disease; Dementia Narcolepsy Neurological disease Eating disorder; Epilepsy; Pain Diabetic neuropathy; Musculoskeletal pain Dementia Alcohol use disorders Allergic rhinitis Alzheimer disease Alzheimer disease; Schizophrenia Anxiety disorder Attention deficit hyperactivity disorder Central nervous system disease Cognitive disorders [ Show all ]
Length	445
Amino acid sequence	MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
UniProt	Q9Y5N1
Protein Data Bank	N/A
GPCR-HGmod model	Q9Y5N1
3D structure model	This predicted structure model is from GPCR-EXP Q9Y5N1.
BioLiP	N/A
Therapeutic Target Database	T64765
ChEMBL	CHEMBL264
IUPHAR	264
DrugBank	BE0000968

Ligand

Name	CHEMBL153207
Molecular formula	C10H17N3
IUPAC name	3-[2-(1H-imidazol-5-yl)ethyl]piperidine
Molecular weight	179.267
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.0
Synonyms	AKOS006312758 3-[2-(1H-imidazol-4-yl)ethyl]piperidine BDBM50150944
Inchi Key	ARRCCCIOHBCTKB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H17N3/c1-2-9(6-11-5-1)3-4-10-7-12-8-13-10/h7-9,11H,1-6H2,(H,12,13)
PubChem CID	11171320
ChEMBL	CHEMBL153207
IUPHAR	N/A
BindingDB	50150944
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	512.86 nM	PMID14640553	ChEMBL
Intrinsic activity	0.34 -	PMID14640553	ChEMBL
Intrinsic activity	34.0 %	PMID26390077	ChEMBL
Ki	181.97 nM	PMID26390077, PMID14640553	ChEMBL
Ki	182.0 nM	PMID26390077	BindingDB
Selectivity	1.8 -	PMID14640553	ChEMBL

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