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GPCR

NameP2Y purinoceptor 1
SpeciesMeleagris gallopavo (Wild turkey)
GeneP2RY1
Synonym6H1 orphan receptor
ADP receptor
P2Y1
Purinergic receptor
DiseaseN/A for non-human GPCRs
Length362
Amino acid sequenceMTEALISAALNGTQPELLAGGWAAGNASTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTGVRRNKTITCYDTTADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPQMCAFNDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSEEMTLNILTEYKQNGDTSL
UniProtP49652
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5720
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3144473
Molecular formulaC11H18N5O9P2+
IUPAC name[(2R,3S,5R)-5-(6-amino-1-methylpurin-1-ium-9-yl)-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate
Molecular weight426.239
Hydrogen bond acceptor12
Hydrogen bond donor5
XlogP-3.5
Synonyms1-Methyl-6-amino-9-(3-O,5-O-diphosphono-2-deoxy-beta-D-erythro-pentofuranosyl)-9H-purin-1-ium
Inchi KeyISFCHLQYVOFFBP-XLPZGREQSA-O
Inchi IDInChI=1S/C11H17N5O9P2/c1-15-4-14-11-9(10(15)12)13-5-16(11)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8,12H,2-3H2,1H3,(H4,17,18,19,20,21,22)/p+1/t6-,7+,8+/m0/s1
PubChem CID10788499
ChEMBLCHEMBL3144473
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.

Experimental Data

ParameterValueReferenceDatabase source
IC5054900.0 nMPMID9457242ChEMBL
Max inhibition100.0 %PMID9457242ChEMBL

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