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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL460680
Molecular formula	C22H33F2N7O4
IUPAC name	2-[5-[(1R)-1-[(2-amino-2-methylpropanoyl)amino]-4,4-difluoro-4-phenylbutyl]tetrazol-1-yl]ethyl N-(4-hydroxybutyl)carbamate
Molecular weight	497.548
Hydrogen bond acceptor	10
Hydrogen bond donor	4
XlogP	1.0
Synonyms	BDBM50243597 (R)-2-(5-(1-(2-amino-2-methylpropanamido)-4,4-difluoro-4-phenylbutyl)-1H-tetrazol-1-yl)ethyl 4-hydroxybutylcarbamate
Inchi Key	ATQNZOMJKQGZHT-QGZVFWFLSA-N
Inchi ID	InChI=1S/C22H33F2N7O4/c1-21(2,25)19(33)27-17(10-11-22(23,24)16-8-4-3-5-9-16)18-28-29-30-31(18)13-15-35-20(34)26-12-6-7-14-32/h3-5,8-9,17,32H,6-7,10-15,25H2,1-2H3,(H,26,34)(H,27,33)/t17-/m1/s1
PubChem CID	24894012
ChEMBL	CHEMBL460680
IUPHAR	N/A
BindingDB	50243597
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.27 nM	PMID18554903	BindingDB,ChEMBL

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