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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL460680
Molecular formulaC22H33F2N7O4
IUPAC name2-[5-[(1R)-1-[(2-amino-2-methylpropanoyl)amino]-4,4-difluoro-4-phenylbutyl]tetrazol-1-yl]ethyl N-(4-hydroxybutyl)carbamate
Molecular weight497.548
Hydrogen bond acceptor10
Hydrogen bond donor4
XlogP1.0
SynonymsBDBM50243597
(R)-2-(5-(1-(2-amino-2-methylpropanamido)-4,4-difluoro-4-phenylbutyl)-1H-tetrazol-1-yl)ethyl 4-hydroxybutylcarbamate
Inchi KeyATQNZOMJKQGZHT-QGZVFWFLSA-N
Inchi IDInChI=1S/C22H33F2N7O4/c1-21(2,25)19(33)27-17(10-11-22(23,24)16-8-4-3-5-9-16)18-28-29-30-31(18)13-15-35-20(34)26-12-6-7-14-32/h3-5,8-9,17,32H,6-7,10-15,25H2,1-2H3,(H,26,34)(H,27,33)/t17-/m1/s1
PubChem CID24894012
ChEMBLCHEMBL460680
IUPHARN/A
BindingDB50243597
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC500.27 nMPMID18554903BindingDB,ChEMBL

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