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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesHomo sapiens (Human)
GeneHCAR2
SynonymG-protein coupled receptor HM74A
G-protein coupled receptor 109A
PUMAG
Nicotinic acid receptor
HCA2 receptor
[ Show all ]
DiseaseHyperlipidaemia
Acute ischemic stroke
Arteriosclerosis
Atherosclerosis
Cardiovascular disorder
[ Show all ]
Length363
Amino acid sequenceMNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProtQ8TDS4
Protein Data BankN/A
GPCR-HGmod modelQ8TDS4
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDS4.
BioLiPN/A
Therapeutic Target DatabaseT00864
ChEMBLCHEMBL3785
IUPHAR312
DrugBankBE0000635

Ligand

NameCHEMBL2036825
Molecular formulaC12H14N2O4
IUPAC name5-pentyl-1H-pyrano[2,3-d]pyrimidine-2,4,7-trione
Molecular weight250.254
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.2
SynonymsSCHEMBL12602392
2H-Pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-trione, 5-pentyl-
BDBM50384627
915209-50-6
Inchi KeyAUIXOCKTXJWILY-UHFFFAOYSA-N
Inchi IDInChI=1S/C12H14N2O4/c1-2-3-4-5-7-6-8(15)18-11-9(7)10(16)13-12(17)14-11/h6H,2-5H2,1H3,(H2,13,14,16,17)
PubChem CID15605645
ChEMBLCHEMBL2036825
IUPHARN/A
BindingDB50384627
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5019.0 nMPMID24900372BindingDB,ChEMBL

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