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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesHomo sapiens (Human)
GeneHCAR2
SynonymG-protein coupled receptor HM74A
G-protein coupled receptor 109A
PUMAG
Nicotinic acid receptor
HCA2 receptor
[ Show all ]
DiseaseHyperlipidaemia
Acute ischemic stroke
Arteriosclerosis
Atherosclerosis
Cardiovascular disorder
[ Show all ]
Length363
Amino acid sequenceMNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProtQ8TDS4
Protein Data BankN/A
GPCR-HGmod modelQ8TDS4
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDS4.
BioLiPN/A
Therapeutic Target DatabaseT00864
ChEMBLCHEMBL3785
IUPHAR312
DrugBankBE0000635

Known ligands

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Total entries: 781
Page:  / 8 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
20032D structureCHEMBL2036255C22H19ClN4O2406.874 / 13.9Yes
29902D structureCHEMBL2057611C13H16N2O2232.2833 / 22.8Yes
33032D structureCHEMBL393083C8H10N2O2S198.244 / 21.0Yes
37592D structureCHEMBL3299115C18H19NO5329.3525 / 22.8Yes
4418752D structure4-Methoxycinnamic acidC10H10O3178.1873 / 11.8Yes
49272D structureCHEMBL245457C6H9N3O2155.1574 / 3-2.8Yes
50422D structureCHEMBL1672760C12H12N2O3232.2394 / 10.3Yes
52842D structureCHEMBL1672755C9H8N2O3S224.2344 / 20.2Yes
55302D structureCHEMBL559204C14H13N3O2S2319.3976 / 22.9Yes
60962D structureCHEMBL1939014C16H14N2O4298.2985 / 11.7Yes
62982D structure3-CYANO-5-HYDROXYBENZOIC ACIDC8H5NO3163.1324 / 20.9Yes
69042D structureCHEMBL2036824C13H10N2O4S290.2935 / 20.7Yes
69912D structureCHEMBL1672746C11H11FN2O3238.2185 / 10.6Yes
71572D structureCHEMBL1224147C16H14FN3O2299.3055 / 11.9Yes
77222D structureCHEMBL1939046C19H22N2O4342.3955 / 13.5Yes
86062D structureCHEMBL482698C20H21NO4339.3914 / 33.8Yes
86332D structureCHEMBL223700C12H8F2O4254.1896 / 11.9Yes
92552D structureCHEMBL391812C21H20N2O4364.4015 / 23.9Yes
92742D structureCHEMBL1085875C19H18N4O4366.3776 / 32.6Yes
105522D structureCHEMBL1672638C16H14N2O4298.2985 / 11.5Yes
112292D structureCHEMBL2057603C10H12N2O3208.2174 / 20.3Yes
112302D structureCHEMBL2057604C10H12N2O3208.2174 / 20.3Yes
125212D structureSCH-900271C14H16N2O4276.2924 / 21.6Yes
143042D structure5-Hydroxynicotinic acidC6H5NO3139.114 / 20.0Yes
146722D structureCHEMBL2036825C12H14N2O4250.2544 / 21.2Yes
154162D structureCHEMBL3298701C20H19NO4337.3754 / 33.9Yes
156732D structureCHEMBL2057609C15H14N2O3270.2884 / 22.2Yes
168422D structureCHEMBL484605C20H17N5O5407.3867 / 31.6Yes
171642D structureCHEMBL1672640C16H18F2N2O3324.3286 / 13.3Yes
5577612D structureCHEMBL1770177C18H16N4O5368.3498 / 4-1.0Yes
5577622D structureCHEMBL1770178C18H16N4O5368.3498 / 4-1.0Yes
172812D structurePropyl FumarateC7H10O4158.1534 / 10.8Yes
180792D structure4-Chlorobenzyl FumarateC11H9ClO4240.6394 / 12.4Yes
184102D structureCHEMBL385103C12H8F2O4254.1896 / 11.9Yes
5578222D structureCHEMBL1770356C18H21N5O5387.3969 / 4-1.3Yes
4651792D structureCHEMBL3589793C22H18FNO4379.3875 / 34.4Yes
5220452D structureSCHEMBL3187607C9H9ClN4O2240.6473 / 21.5Yes
5220502D structureSCHEMBL3179786C11H13ClN4O2268.7013 / 22.4Yes
220642D structureCHEMBL375534C8H8O4168.1484 / 10.8Yes
4425832D structure2-Bromobenzyl FumarateC11H9BrO4285.0934 / 12.1Yes
236332D structureCHEMBL1085148C19H22N4O4370.4096 / 32.1Yes
5533662D structureD0V9LRC22H24Cl2N4O2447.364 / 13.9Yes
5580142D structureCHEMBL1770355C17H19N5O5373.3699 / 4-1.7Yes
245452D structure6,6-Dimethyl-1,4,5,6-tetrahydrocyclopentapyrazole-3-carboxylic acidC9H12N2O2180.2073 / 21.6Yes
254672D structure3-hydroxy-5-(trifluoromethyl)benzoic AcidC8H5F3O3206.126 / 22.0Yes
255182D structureCHEMBL3298700C20H19NO3321.3763 / 24.3Yes
256012D structureCHEMBL1939039C15H14N2O4286.2875 / 11.4Yes
4661362D structureCHEMBL3589791C23H21NO4375.4244 / 34.7Yes
268532D structureCHEMBL376889C12H9FO4236.1985 / 11.8Yes
287342D structurePentyl FumarateC9H14O4186.2074 / 11.7Yes
290652D structureCHEMBL398762C20H20N6O3392.4197 / 31.7Yes
295452D structureCHEMBL1085655C26H24FNO4433.4795 / 35.1No
297722D structureCHEMBL1939022C17H16N2O5328.3246 / 11.7Yes
5581892D structureCHEMBL1084030C23H21FN4O5452.4429 / 32.7Yes
302982D structureCHEMBL519689C14H14N6266.3084 / 21.9Yes
309222D structureCHEMBL3299013C19H18N2O4338.3635 / 33.0Yes
309282D structureCHEMBL2036817C13H8N2O4256.2174 / 20.4Yes
314292D structureCHEMBL1672639C15H16F2N2O3310.3016 / 12.7Yes
316862D structureCHEMBL1224074C17H17N3O3311.3415 / 12.7Yes
333552D structureCHEMBL1085535C11H12N6228.2594 / 21.0Yes
343792D structureCHEMBL248852C20H21N5O3379.426 / 22.6Yes
347522D structureCHEMBL1939017C13H16N2O5280.286 / 10.5Yes
351592D structureCHEMBL1939034C14H13N3O5303.2747 / 10.6Yes
354202D structureCHEMBL560254C10H17N3O2211.2654 / 22.3Yes
355882D structure5-Fluoronicotinic acidC6H4FNO2141.1014 / 10.5Yes
365572D structureCHEMBL1672734C12H10F2N2O3268.226 / 11.3Yes
367992D structureCHEMBL2036957C14H16N2O4276.2924 / 21.8Yes
376292D structureCHEMBL235741C22H19NO3345.3983 / 25.4No
381052D structureCHEMBL237036C16H14N4O4S358.3727 / 32.1Yes
383852D structureCHEMBL1224221C17H17N3O2295.3424 / 12.2Yes
395022D structureCHEMBL491242C26H28N4O412.5373 / 15.1No
396802D structureCHEMBL1770358C18H20FN5O4389.3879 / 3-0.8Yes
5584962D structureCHEMBL485196C21H22N2O5382.4166 / 32.9Yes
402092D structureCHEMBL1939018C12H14N2O4250.2545 / 11.3Yes
410622D structure3-hydroxy-5-methylbenzoic acidC8H8O3152.1493 / 21.5Yes
411362D structureGSK-256073C10H13ClN4O2256.693 / 22.3Yes
412102D structureCHEMBL1085616C25H24F2N4O4482.4888 / 33.8Yes
412862D structureCHEMBL2036090C21H26N4O2366.4654 / 13.0Yes
412872D structureCHEMBL490215C21H26N4O2366.4654 / 13.0Yes
420792D structureCHEMBL1086031C27H25FN2O4460.5056 / 34.7Yes
423732D structure5-isopropyl-1H-pyrazole-3-carboxylic acidC7H10N2O2154.1693 / 21.2Yes
429082D structureCHEMBL1086356C20H21NO5355.395 / 42.6Yes
430242D structureCHEMBL2036252C25H26N4O3430.5085 / 14.1Yes
5586132D structureMK-6892C19H22N4O5386.4088 / 32.3Yes
442162D structureCipargaminC19H14Cl2FN3O390.2393 / 33.9Yes
442532D structureCHEMBL492027C27H30N4O2442.5634 / 14.6Yes
443812D structureCHEMBL1224220C16H14ClN3O2315.7574 / 12.4Yes
446452D structureCHEMBL1939011C10H10N2O4222.25 / 10.2Yes
5228552D structureSCHEMBL3179805C11H15ClN4O2270.7173 / 12.6Yes
466942D structure3-(5-ethylfuran-2-yl)prop-2-enoic acidC9H10O3166.1763 / 11.8Yes
468012D structure5-methyl-1H-pyrrole-3-carboxylic acidC6H7NO2125.1272 / 21.6Yes
479332D structure14779-25-0C8H8O3152.1493 / 11.4Yes
4435962D structure4-(Dimethylamino)cinnamic acidC11H13NO2191.233 / 11.9Yes
489832D structureCHEMBL562675C14H13N3O2S2319.3976 / 23.0Yes
495802D structureCHEMBL2059222C11H14N2O2206.2453 / 22.1Yes
495812D structureCHEMBL2059223C11H14N2O2206.2453 / 22.1Yes
4690242D structureCHEMBL3589837C20H17NO4S367.4195 / 34.4Yes
511202D structureMK 1903C8H8N2O2164.1643 / 20.6Yes
511212D structureCHEMBL2059221C8H8N2O2164.1643 / 20.6Yes
517162D structureCHEMBL2036950C13H16N2O4264.2814 / 21.5Yes

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