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Name | Melanocortin receptor 4 |
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Species | Homo sapiens (Human) |
Gene | MC4R |
Synonym | MC4-R MC4 receptor |
Disease | Obesity; Sexual dysfunction Obesity; Diabetes Obesity Metabolic disorders Sexual dysfunction [ Show all ] |
Length | 332 |
Amino acid sequence | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY |
UniProt | P32245 |
Protein Data Bank | N/A |
GPCR-HGmod model | P32245 |
3D structure model | This predicted structure model is from GPCR-EXP P32245. |
BioLiP | N/A |
Therapeutic Target Database | T72458 |
ChEMBL | CHEMBL259 |
IUPHAR | 285 |
DrugBank | N/A |
Name | CHEMBL226227 |
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Molecular formula | C35H47FN4 |
IUPAC name | 1-[1-(4-fluorophenyl)-2-[4-[3-(2-methyl-6-phenylphenyl)propyl]piperazin-1-yl]ethyl]-4-propan-2-ylpiperazine |
Molecular weight | 542.787 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 6.7 |
Synonyms | BDBM50202933 (+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazin-1-yl)ethyl]-4-[3-(3-methylbiphenyl-2-yl)propyl]piperazine |
Inchi Key | JBXYADWMJLOTTL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C35H47FN4/c1-28(2)39-23-25-40(26-24-39)35(31-14-16-32(36)17-15-31)27-38-21-19-37(20-22-38)18-8-13-33-29(3)9-7-12-34(33)30-10-5-4-6-11-30/h4-7,9-12,14-17,28,35H,8,13,18-27H2,1-3H3 |
PubChem CID | 44423459 |
ChEMBL | CHEMBL226227 |
IUPHAR | N/A |
BindingDB | 50202933 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 24.3 nM | PMID17234422 | BindingDB,ChEMBL |
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