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Name | Histamine H3 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH3 |
Synonym | HH3R H3R H3 receptor GPCR97 G-protein coupled receptor 97 |
Disease | Obese insulin-resistant disorders Excessive daytime sleepiness Sleep disorders Schizophrenia Pain [ Show all ] |
Length | 445 |
Amino acid sequence | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK |
UniProt | Q9Y5N1 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9Y5N1 |
3D structure model | This predicted structure model is from GPCR-EXP Q9Y5N1. |
BioLiP | N/A |
Therapeutic Target Database | T64765 |
ChEMBL | CHEMBL264 |
IUPHAR | 264 |
DrugBank | BE0000968 |
Name | CHEMBL1950743 |
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Molecular formula | C21H29N3O2 |
IUPAC name | 3-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-5,5-dimethyl-1,4-dihydropyridazin-6-one |
Molecular weight | 355.482 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 3.3 |
Synonyms | BDBM50364958 SCHEMBL1375906 |
Inchi Key | AUNMHWAGSWQKHU-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H29N3O2/c1-21(2)14-19(22-23-20(21)25)15-6-8-17(9-7-15)26-18-10-12-24(13-11-18)16-4-3-5-16/h6-9,16,18H,3-5,10-14H2,1-2H3,(H,23,25) |
PubChem CID | 24993178 |
ChEMBL | CHEMBL1950743 |
IUPHAR | N/A |
BindingDB | 50364958 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 0.8 nM | PMID22290075 | BindingDB,ChEMBL |
Ki | 2.7 nM | PMID22290075, PMID24513042 | BindingDB,ChEMBL |
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