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Name | Alpha-2C adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRA2C |
Synonym | alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I [ Show all ] |
Disease | Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease [ Show all ] |
Length | 462 |
Amino acid sequence | MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ |
UniProt | P18825 |
Protein Data Bank | N/A |
GPCR-HGmod model | P18825 |
3D structure model | This predicted structure model is from GPCR-EXP P18825. |
BioLiP | N/A |
Therapeutic Target Database | T01777 |
ChEMBL | CHEMBL1916 |
IUPHAR | 27 |
DrugBank | BE0004864, BE0000342, BE0004888 |
Name | CHEMBL432155 |
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Molecular formula | C12H14N4O |
IUPAC name | N-(1H-imidazol-2-yl)-5-methyl-3,4-dihydro-2H-1,4-benzoxazin-6-amine |
Molecular weight | 230.271 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 3 |
XlogP | 2.0 |
Synonyms | (1H-Imidazol-2-yl)-(5-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amine BDBM50055830 SCHEMBL7803545 2-[[(5-Methyl-2,3-dihydro-4H-1,4-benzoxazin)-6-yl]amino]-1H-imidazole |
Inchi Key | JDFLCCTUDMVCCS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H14N4O/c1-8-9(16-12-14-4-5-15-12)2-3-10-11(8)13-6-7-17-10/h2-5,13H,6-7H2,1H3,(H2,14,15,16) |
PubChem CID | 9859437 |
ChEMBL | CHEMBL432155 |
IUPHAR | N/A |
BindingDB | 50055830 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 110.0 nM | PMID9016324 | BindingDB,ChEMBL |
IA | 0.64 - | PMID9016324 | ChEMBL |
Ki | 230.0 nM | PMID9016324 | BindingDB,ChEMBL |
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