You can:
Name | Metabotropic glutamate receptor 8 |
---|---|
Species | Homo sapiens (Human) |
Gene | GRM8 |
Synonym | mGluR8b mGluR8 mGlu8 receptor Gprc1h glutamate receptor [ Show all ] |
Disease | N/A |
Length | 908 |
Amino acid sequence | MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI |
UniProt | O00222 |
Protein Data Bank | 6bsz, 6bt5, 6e5v |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 6bsz. |
BioLiP | BL0432251,BL0432252, BL0403876,BL0403877, BL0403874,BL0403875 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3228 |
IUPHAR | 296 |
DrugBank | BE0000835 |
Name | CHEMBL300330 |
---|---|
Molecular formula | C7H12N2O4 |
IUPAC name | (2R,4R)-4-amino-1-methylpyrrolidine-2,4-dicarboxylic acid |
Molecular weight | 188.183 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 3 |
XlogP | -6.0 |
Synonyms | 2,4-Pyrrolidinedicarboxylicacid, 4-amino-1-methyl-, (2R,4R)- DTXSID10658238 AKOS027402606 (2R,4R)-4-Amino-1-methyl-pyrrolidine-2,4-dicarboxylic acid 213619-98-8 [ Show all ] |
Inchi Key | AWGRHEDNWXKCFJ-CLZZGJSISA-N |
Inchi ID | InChI=1S/C7H12N2O4/c1-9-3-7(8,6(12)13)2-4(9)5(10)11/h4H,2-3,8H2,1H3,(H,10,11)(H,12,13)/t4-,7-/m1/s1 |
PubChem CID | 44302818 |
ChEMBL | CHEMBL300330 |
IUPHAR | N/A |
BindingDB | 50071164 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <300000.0 nM | PMID9873471 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218