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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL2048808
Molecular formulaC23H28N2O3
IUPAC name1-(2-benzyl-2,7-diazaspiro[3.5]nonan-7-yl)-2-(4-methoxyphenoxy)ethanone
Molecular weight380.488
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.3
SynonymsBDBM50386943
Inchi KeyAWIDXSUFNLMVFO-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H28N2O3/c1-27-20-7-9-21(10-8-20)28-16-22(26)25-13-11-23(12-14-25)17-24(18-23)15-19-5-3-2-4-6-19/h2-10H,11-18H2,1H3
PubChem CID70694647
ChEMBLCHEMBL2048808
IUPHARN/A
BindingDB50386943
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC502980.0 nMPMID22677316BindingDB,ChEMBL
Inhibition-22.0 %PMID22677316ChEMBL

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