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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameSCHEMBL4805648
Molecular formulaC19H23BrFN3O3S
IUPAC name4-bromo-N-[5-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-2-fluorophenyl]-2-methoxybenzenesulfonamide
Molecular weight472.373
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP3.5
SynonymsCHEMBL2364463
Inchi KeyAWMCTNJQOUASMF-BETUJISGSA-N
Inchi IDInChI=1S/C19H23BrFN3O3S/c1-12-10-24(11-13(2)22-12)15-5-6-16(21)17(9-15)23-28(25,26)19-7-4-14(20)8-18(19)27-3/h4-9,12-13,22-23H,10-11H2,1-3H3/t12-,13+
PubChem CID69198407
ChEMBLCHEMBL2364463
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50100.0 nMDOI: http://dx.doi.org/10.6019/CHEMBL2364335ChEMBL

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