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GLASS

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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1771103
Molecular formula	C21H26N6O
IUPAC name	6-methyl-2-[2-[(1S,2R)-2-[1-(5-methylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]pyrimidine-4-carbonitrile
Molecular weight	378.48
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.7
Synonyms	BDBM50342702 6-methyl-2-(2-((1S,2R)-2-(1-(5-methylpyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethoxy)pyrimidine-4-carbonitrile
Inchi Key	LNSCXGSOFFKSIA-IEBWSBKVSA-N
Inchi ID	InChI=1S/C21H26N6O/c1-14-12-23-20(24-13-14)27-6-3-16(4-7-27)19-10-17(19)5-8-28-21-25-15(2)9-18(11-22)26-21/h9,12-13,16-17,19H,3-8,10H2,1-2H3/t17-,19-/m1/s1
PubChem CID	54586781
ChEMBL	CHEMBL1771103
IUPHAR	N/A
BindingDB	50342702
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.0 nM	PMID21273063	BindingDB,ChEMBL

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