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Name | Muscarinic acetylcholine receptor M5 |
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Species | Homo sapiens (Human) |
Gene | CHRM5 |
Synonym | M5R M5 receptor cholinergic receptor cholinergic receptor, muscarinic 5 |
Disease | Urinary incontinence Colitis Dysmenorrhea Irritable bowel syndrome Myasthenia gravis [ Show all ] |
Length | 532 |
Amino acid sequence | MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP |
UniProt | P08912 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T79961 |
ChEMBL | CHEMBL2035 |
IUPHAR | 17 |
DrugBank | BE0000247, BE0004890 |
Name | CHEMBL2381694 |
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Molecular formula | C17H12F3NO4 |
IUPAC name | 1-(2-phenoxyethyl)-5-(trifluoromethoxy)indole-2,3-dione |
Molecular weight | 351.281 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 3.7 |
Synonyms | ML326 VU0467903-1 MLS004576079 BDBM50433574 ML-326 [ Show all ] |
Inchi Key | LSQVHDRSPDDZCD-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H12F3NO4/c18-17(19,20)25-12-6-7-14-13(10-12)15(22)16(23)21(14)8-9-24-11-4-2-1-3-5-11/h1-7,10H,8-9H2 |
PubChem CID | 57525860 |
ChEMBL | CHEMBL2381694 |
IUPHAR | N/A |
BindingDB | 50433574 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 407.38 nM | PMID23562060 | ChEMBL |
EC50 | 410.0 nM | PMID23562060 | ChEMBL |
EC50 | 550.0 nM | PubChem BioAssay data set | ChEMBL |
EC50 | 51600.0 nM | PubChem BioAssay data set | ChEMBL |
Emax | 91.0 % | PMID23562060 | ChEMBL |
FC | 20.0 - | PMID23562060 | ChEMBL |
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