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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMuscarinic acetylcholine receptor M5
SpeciesHomo sapiens (Human)
GeneCHRM5
SynonymM5R
M5 receptor
cholinergic receptor, muscarinic 5
cholinergic receptor
DiseaseSchizophrenia
Urinary incontinence
Stomach ulcer
Neurological disease
Myasthenia gravis
[ Show all ]
Length532
Amino acid sequenceMEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProtP08912
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT79961
ChEMBLCHEMBL2035
IUPHAR17
DrugBankBE0004890, BE0000247

Known ligands

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Total entries: 1462
Page:  / 15 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
32D structureCHEMBL3105203C24H17F3N2O2S454.4676 / 05.2No
4416792D structureCHEMBL1602658C23H28N2O5S444.5466 / 02.6Yes
5222D structureCHEMBL2407175C24H36N4O3428.5775 / 02.7Yes
10232D structureCHEMBL2205816C18H20N2O280.3713 / 11.8Yes
22592D structure1-(cyclohexylmethyl)pyrrolidineC11H21N167.2961 / 03.1Yes
31282D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
35502D structureCHEMBL2312348C22H25NO3351.4464 / 03.1Yes
40082D structureCHEMBL215894C37H41Cl3N4O4712.1095 / 35.9No
43182D structuresulconazoleC18H15Cl3N2S397.7422 / 06.1No
49182D structureCHEMBL239657C14H21N2O+233.3352 / 11.8Yes
49862D structureCHEMBL255692C36H46Cl2N2O2609.6764 / 4N/ANo
56662D structureAC1L1HUKC29H28ClN3O4518.014 / 25.2No
57472D structureAHOUBRCZNHFOSL-UHFFFAOYSA-NC19H20FNO3329.3715 / 13.5Yes
57592D structureparoxetineC19H20FNO3329.3715 / 13.5Yes
4592792D structureBDBM86295C12H16N3O2+234.2792 / 00.0Yes
66122D structurecarbacholC6H15ClN2O2182.6483 / 1N/AN/A
66852D structureCHEMBL214029C38H43F3N4O4676.7818 / 34.7No
68362D structureCID 49797317C14H18N2O6310.3068 / 2N/AN/A
4637252D structureCHEMBL3633757C26H24BrNO4494.3855 / 05.4No
71902D structureCHEMBL2024331C23H33N3O3399.5354 / 13.6Yes
77812D structureCHEMBL376295C19H25N5O5S2467.55912 / 02.8No
95332D structureGlycopyrroniumC19H28NO3+318.4373 / 13.1Yes
98542D structureAC-42C20H31NO301.4742 / 05.2No
101792D structureCHEMBL194206C23H30FN5O2427.5246 / 12.7Yes
4421162D structureCHEMBL3353272C25H19F3N2O3452.4336 / 04.1Yes
103902D structureN-Allyl Brucine IodideC26H31N2O4+435.5444 / 01.6Yes
107052D structureCHEMBL213709C39H45F3N4O4690.8088 / 25.1No
107492D structureCHEMBL3287723C25H32O7444.5247 / 25.7No
109102D structureCHEMBL169494C19H22N2278.3992 / 02.4Yes
4421472D structureCHEMBL3353282C29H30N2O4470.5694 / 05.0Yes
114952D structureMLS000624518C17H15NO3281.3113 / 02.9Yes
119142D structureCHEMBL477821C24H29ClN4O424.9733 / 14.1Yes
125452D structureCHEMBL593620C11H24INO2329.2223 / 0N/AN/A
125502D structureCHEMBL593685C11H24INO2329.2223 / 0N/AN/A
127042D structureCHEMBL1083925C20H22ClFN2O360.8573 / 24.3Yes
130592D structureCHEMBL397538C16H19N2O2+271.342 / 11.1Yes
133062D structureAclidiniumC26H30NO4S2+484.6496 / 14.7Yes
137752D structureCHEMBL2312373C22H24BrNO2414.3433 / 04.7Yes
137852D structureCHEMBL557808C19H30INO2S463.4184 / 0N/AN/A
141222D structureCHEMBL466851C15H8BrCl2NO2385.0382 / 04.3Yes
147802D structureCHEMBL443334C16H12FNO3285.2744 / 02.5Yes
151542D structurecremastrineC14H25NO3255.3584 / 12.2Yes
154312D structureCHEMBL568775C23H32NO2+354.5142 / 14.4Yes
154322D structureCHEMBL569089C23H32NO2+354.5142 / 14.4Yes
154392D structureCHEMBL569307C23H32NO2+354.5142 / 14.4Yes
154442D structureCHEMBL568870C23H32NO2+354.5142 / 14.4Yes
154492D structureCHEMBL569760C23H32NO2+354.5142 / 14.4Yes
154722D structureCHEMBL2205829C19H19NO3309.3654 / 12.2Yes
157862D structureCID 44448670C21H28ClNO345.9112 / 2N/AN/A
4422662D structureCHEMBL3354075C26H42N2O2414.6343 / 15.7No
160492D structureCHEMBL596509C21H12F4N2O3416.3328 / 04.6Yes
4423052D structureCHEMBL2059306C24H28N4O2404.5143 / 13.8Yes
169572D structureCHEMBL239865C14H21ClN2O2284.7843 / 1N/AN/A
4423382D structureCHEMBL3361316C24H19ClN2O3418.8773 / 04.1Yes
177172D structureCHEMBL504572C16H8F5NO3357.2368 / 03.8Yes
190852D structureBAS 07465501C20H24ClN3O2373.8814 / 13.7Yes
4424342D structureCHEMBL3329723C20H27N3O4S405.5136 / 02.1Yes
201862D structureimipramineC19H24N2280.4152 / 04.8Yes
4424632D structureCHEMBL3353265C24H16F2N2O4434.3996 / 03.5Yes
205422D structureAQ-RA 741C27H37N5O2463.6265 / 13.1Yes
209742D structureCHEMBL62247C24H26N2O4406.4825 / 14.2Yes
210682D structure1-(2-methylbenzyl)-1H-indole-2,3-dioneC16H13NO2251.2852 / 02.4Yes
4425082D structureCHEMBL3329765C25H27F3N4O3S520.5718 / 13.8No
220672D structureCHEMBL568775C23H32INO2481.4183 / 1N/AN/A
220722D structureCHEMBL569760C23H32INO2481.4183 / 1N/AN/A
220792D structureCHEMBL569089C23H32INO2481.4183 / 1N/AN/A
220822D structureCHEMBL568870C23H32INO2481.4183 / 1N/AN/A
220862D structureCHEMBL569307C23H32INO2481.4183 / 1N/AN/A
5221422D structureCHEMBL3775436C15H26ClNO3303.8274 / 3N/AN/A
5221972D structureCHEMBL3775769C15H26ClNO3303.8274 / 3N/AN/A
221752D structuresuloctidilC20H35NOS337.5663 / 25.8No
222442D structureCHEMBL2111540C25H31N3O2S437.6026 / 04.1Yes
222972D structureCHEMBL512236C15H8ClF2NO2307.6814 / 03.2Yes
225562D structureCHEMBL283036C19H19F3N4360.3846 / 13.6Yes
228722D structuretropicamideC17H20N2O2284.3593 / 11.5Yes
229072D structureMLS002473340C17H12F3NO2319.2835 / 03.6Yes
235822D structureCHEMBL378872C37H41Cl3N4O4712.1095 / 35.9No
245962D structureCHEMBL262198C24H27NO6425.4817 / 2N/AN/A
246342D structureCHEMBL540316C23H28ClNO2385.9323 / 1N/AN/A
257972D structureCHEMBL2042406C20H26INO2439.3373 / 0N/AN/A
258032D structureCHEMBL2042405C20H26INO2439.3373 / 0N/AN/A
258112D structureCHEMBL2042404C20H26INO2439.3373 / 0N/AN/A
258862D structureMLS004576082C18H15F3N2O6412.3219 / 13.2Yes
263812D structureCHEMBL105122C23H24N2O3S408.5165 / 14.4Yes
264402D structureCHEMBL304036C23H24N2O3376.4564 / 14.3Yes
264912D structureCHEMBL506043C17H12F3NO3335.2826 / 03.9Yes
265242D structureCHEMBL2042553C21H25NO6387.4327 / 2N/AN/A
265292D structureCHEMBL2042554C21H25NO6387.4327 / 2N/AN/A
265332D structureCHEMBL2042552C21H25NO6387.4327 / 2N/AN/A
269342D structureterconazoleC26H31Cl2N5O3532.4667 / 04.8No
272182D structureCHEMBL2203713C18H22N4S326.4624 / 22.9Yes
274902D structureCHEMBL2432063C19H29N271.4481 / 04.7Yes
283592D structureCHEMBL593685C11H24NO2+202.3182 / 00.9Yes
283612D structureCHEMBL593620C11H24NO2+202.3182 / 00.9Yes
285412D structureCHEMBL197796C24H33N5O2S455.6216 / 13.1Yes
286192D structureCHEMBL352779C20H23N3O321.4243 / 12.2Yes
289432D structureCHEMBL2407171C20H28N4O4388.4686 / 11.7Yes
291182D structureCHEMBL3105211C24H16ClF3N2O2456.8495 / 05.0Yes
296042D structureCHEMBL2336054C21H29N3O3371.4814 / 02.2Yes
296102D structureCHEMBL2336055C21H29N3O3371.4814 / 02.2Yes

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