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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL346698
Molecular formula	C23H19ClN2O
IUPAC name	4-[5-(4-chlorophenyl)-3-(2-ethoxyphenyl)-1H-pyrrol-2-yl]pyridine
Molecular weight	374.868
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.6
Synonyms	2-(4-Pyridinyl)-3-(2-ethoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrole BDBM50075754 4-[5-(4-Chloro-phenyl)-3-(2-ethoxy-phenyl)-1H-pyrrol-2-yl]-pyridine
Inchi Key	MDNFXHVVRABLPD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H19ClN2O/c1-2-27-22-6-4-3-5-19(22)20-15-21(16-7-9-18(24)10-8-16)26-23(20)17-11-13-25-14-12-17/h3-15,26H,2H2,1H3
PubChem CID	44372676
ChEMBL	CHEMBL346698
IUPHAR	N/A
BindingDB	50075754
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	40.0 nM	PMID10201821	BindingDB,ChEMBL
IC50	500.0 nM	PMID10201821	BindingDB,ChEMBL
IC50	14223.0 nM	N/A	BindingDB
IC50	14223.3 nM	Med Chem Res, (2013) None:None:1	ChEMBL

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