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GPCR

NameSomatostatin receptor type 5
SpeciesHomo sapiens (Human)
GeneSSTR5
SynonymSOMATO
SS-5-R
SS5-R
SS5R
SST5 receptor
DiseaseN/A
Length364
Amino acid sequenceMEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
UniProtP35346
Protein Data BankN/A
GPCR-HGmod modelP35346
3D structure modelThis predicted structure model is from GPCR-EXP P35346.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1792
IUPHAR359
DrugBankBE0002147

Ligand

NameCHEMBL236607
Molecular formulaC27H28F2N4
IUPAC nameN-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]-1-[(4-fluorophenyl)methyl]benzimidazol-2-amine
Molecular weight446.546
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP6.1
Synonyms1-(4-fluorobenzyl)-N-(1-(4-fluorophenethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-amine
BDBM50227118
Inchi KeyBDHINVDMKKOVJL-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H28F2N4/c28-22-9-5-20(6-10-22)13-16-32-17-14-24(15-18-32)30-27-31-25-3-1-2-4-26(25)33(27)19-21-7-11-23(29)12-8-21/h1-12,24H,13-19H2,(H,30,31)
PubChem CID12891558
ChEMBLCHEMBL236607
IUPHARN/A
BindingDB50227118
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID18020390BindingDB,ChEMBL

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