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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL158535
Molecular formula	C24H19ClN2O
IUPAC name	4-[5-(4-chlorophenyl)-3-(2-prop-2-enoxyphenyl)-1H-pyrrol-2-yl]pyridine
Molecular weight	386.879
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.8
Synonyms	2-(4-Pyridinyl)-3-[2-(allyloxy)phenyl]-5-(4-chlorophenyl)-1H-pyrrole BDBM50075749 4-[3-(2-Allyloxy-phenyl)-5-(4-chloro-phenyl)-1H-pyrrol-2-yl]-pyridine
Inchi Key	MOFSVJOQRDKEAF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H19ClN2O/c1-2-15-28-23-6-4-3-5-20(23)21-16-22(17-7-9-19(25)10-8-17)27-24(21)18-11-13-26-14-12-18/h2-14,16,27H,1,15H2
PubChem CID	12967035
ChEMBL	CHEMBL158535
IUPHAR	N/A
BindingDB	50075749
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	17.0 nM	PMID10201821	BindingDB,ChEMBL
IC50	260.0 nM	PMID10201821	BindingDB,ChEMBL
IC50	4742.0 nM	N/A	BindingDB
IC50	4742.42 nM	Med Chem Res, (2013) None:None:1	ChEMBL

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