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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL489402
Molecular formulaC20H22Cl2N2O2
IUPAC name2-(3-chlorophenoxy)-N-(2-chlorophenyl)-N-[[(2R)-pyrrolidin-2-yl]methyl]propanamide
Molecular weight393.308
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.8
SynonymsBDBM50264487
2-(3-chlorophenoxy)-N-(2-chlorophenyl)-N-((R)-pyrrolidin-2-ylmethyl)propanamide
Inchi KeyBETBBRQIGQOQCK-BZSJEYESSA-N
Inchi IDInChI=1S/C20H22Cl2N2O2/c1-14(26-17-8-4-6-15(21)12-17)20(25)24(13-16-7-5-11-23-16)19-10-3-2-9-18(19)22/h2-4,6,8-10,12,14,16,23H,5,7,11,13H2,1H3/t14?,16-/m1/s1
PubChem CID44579881
ChEMBLCHEMBL489402
IUPHARN/A
BindingDB50264487
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity70.0 %PMID18722770ChEMBL
EC50780.0 nMPMID18722770BindingDB,ChEMBL

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