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GLASS

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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	CHEMBL212370
Molecular formula	C18H19ClN4
IUPAC name	2-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]imidazo[1,2-a]pyridine
Molecular weight	326.828
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.9
Synonyms	ZINC21403 2-{[4-(4-chlorophenyl)piperazinyl]methyl}-4-hydroimidazo[1,2-a]pyridine KB-272910 MolPort-002-310-587 2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo[1,2-a]pyridine AKOS003343306 ST50832909 2-{[4-(4-chlorophenyl)piperazin-1-yl]methyl}imidazo[1,2-a]pyridine L015345 NSWRCNIUQFRZFO-UHFFFAOYSA-N 2-[[4-(4-Chlorophenyl)-1-piperazinyl]methyl]imidazol[1,2-a]pyridine BDBM50189842 STK482278 2-{[4-(4-chlorophenyl)piperazino]methyl}imidazo[1,2-a]pyridine imidazo[1,2-a]pyridine,2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]- MCULE-7527996920 182181-15-3 AC1O68N5 SCHEMBL8172908 2-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]imidazo[1,2-a]pyridine [ Show all ]
Inchi Key	NSWRCNIUQFRZFO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
PubChem CID	6469918
ChEMBL	CHEMBL212370
IUPHAR	N/A
BindingDB	50189842
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	6.0 %	PMID16789750	ChEMBL
Activity	18.0 %	PMID16789750	ChEMBL
EC50	1.8 nM	PMID16789750	BindingDB,ChEMBL
EC50	2.6 nM	PMID16789750	BindingDB,ChEMBL
Ki	7.0 nM	PMID16789750	BindingDB,ChEMBL

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