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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Mus musculus (Mouse)
Gene	Gcgr
Synonym	GGR GL-R glucagon receptor GR
Disease	N/A for non-human GPCRs
Length	485
Amino acid sequence	MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT
UniProt	Q61606
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4773
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL158989
Molecular formula	C22H14FN3
IUPAC name	4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-pyrrol-2-yl]benzonitrile
Molecular weight	339.373
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.4
Synonyms	4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-pyrrole-2-yl]benzonitrile 4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-yl]-benzonitrile BDBM50075751
Inchi Key	NVWTWHYQHRAFNN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H14FN3/c23-19-7-5-16(6-8-19)20-13-21(17-3-1-15(14-24)2-4-17)26-22(20)18-9-11-25-12-10-18/h1-13,26H
PubChem CID	44373083
ChEMBL	CHEMBL158989
IUPHAR	N/A
BindingDB	50075751
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	230.0 nM	PMID10201821	BindingDB,ChEMBL
Inhibition	42.0 %	PMID10201821	ChEMBL

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