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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymGPCR105
H4 receptor
H4R
HH4R
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL448085
Molecular formulaC12H17N7
IUPAC name4-imidazol-1-yl-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Molecular weight259.317
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP0.2
Synonyms1070216-86-2
4-Imidazol-1-yl-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylamine
SCHEMBL2166146
Inchi KeyOGCXUIJSMCCAKM-UHFFFAOYSA-N
Inchi IDInChI=1S/C12H17N7/c1-17-4-6-18(7-5-17)10-8-11(16-12(13)15-10)19-3-2-14-9-19/h2-3,8-9H,4-7H2,1H3,(H2,13,15,16)
PubChem CID25130230
ChEMBLCHEMBL448085
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC507943.28 nMPMID18811133ChEMBL
Efficacy56.0 %PMID18811133ChEMBL

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