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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymH4 receptor
H4R
HH4R
GPCR105
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Known ligands

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Total entries: 171
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GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
55122D structureCHEMBL522019C15H20N6O300.3667 / 10.7Yes
105102D structureCHEMBL446896C10H17N5207.2815 / 10.5Yes
150642D structureCHEMBL494687C14H24N4248.3744 / 13.3Yes
163402D structureSCHEMBL605165C19H25N5323.4445 / 22.8Yes
193072D structureCHEMBL492288C15H18IN5395.2485 / 12.4Yes
246782D structureSCHEMBL607510C19H21N5319.4125 / 13.0Yes
301402D structureSCHEMBL604679C13H23N5249.3625 / 11.8Yes
343672D structureCHEMBL492662C13H24N6264.3776 / 11.3Yes
402672D structureCHEMBL494093C17H21N5295.395 / 12.1Yes
468222D structureJNJ-39758979C11H19N5221.3085 / 20.7Yes
497572D structureSCHEMBL606762C20H27N5337.4715 / 23.7Yes
554782D structureCHEMBL455016C14H25N5263.3895 / 12.5Yes
615542D structureSCHEMBL604437C18H25N5O327.4326 / 21.3Yes
616582D structureSCHEMBL603307C19H29N5O2359.4747 / 22.2Yes
630942D structureCHEMBL493885C19H22N6334.4276 / 12.2Yes
659692D structureCHEMBL495083C16H18N6294.3626 / 11.5Yes
671822D structureSCHEMBL606923C27H33N5427.5965 / 25.1No
5536592D structure1-MethylhistamineC6H11N3125.1752 / 1-0.6Yes
810142D structureSCHEMBL604850C15H23N5273.3845 / 21.8Yes
827072D structureCHEMBL1079516C16H25N5287.4115 / 22.3Yes
882872D structureCHEMBL522841C19H21N5319.4125 / 13.0Yes
955802D structureCHEMBL495341C12H22N4O238.3355 / 11.9Yes
964392D structureCHEMBL506187C14H25N5263.3895 / 12.2Yes
993232D structureCHEMBL492227C14H18N6270.346 / 10.7Yes
1014312D structureCHEMBL492287C15H18ClN5303.7945 / 12.4Yes
1040322D structureCHEMBL444484C13H22N6O278.367 / 10.2Yes
1078172D structureJMC516547 Compound 5C15H16N6280.3356 / 21.0Yes
1078602D structureCHEMBL492677C16H22N6298.3946 / 21.9Yes
1084412D structureCHEMBL493719C16H21N5O299.3786 / 11.8Yes
1108572D structureSCHEMBL605799C20H27N5337.4715 / 23.3Yes
1126222D structureCHEMBL494723C16H21N5283.3795 / 12.1Yes
1150412D structureCHEMBL493462C17H19N5293.3745 / 11.8Yes
1152862D structureCHEMBL493100C14H27N5265.4055 / 12.4Yes
1203862D structureCHEMBL494576C13H19N7273.3446 / 1-0.1Yes
1215462D structureCHEMBL495342C13H22N4234.3474 / 02.2Yes
1230642D structureCHEMBL493261C13H23N5249.3625 / 11.8Yes
1235872D structureCHEMBL2376803C16H22N6298.3946 / 22.1Yes
1245162D structureJNJ-7777120C14H16ClN3O277.7522 / 12.3Yes
1253992D structureCHEMBL451108C15H19N5269.3525 / 11.7Yes
1262482D structureCHEMBL489663C13H23N5249.3625 / 11.8Yes
1272262D structureCHEMBL447151C13H22N4O250.3462 / 10.8Yes
1291282D structureCHEMBL1081683C17H27N5301.4385 / 22.8Yes
1347892D structureCHEMBL492900C17H20N6308.3896 / 11.9Yes
1361572D structureCHEMBL1089040C20H27N5337.4715 / 23.2Yes
1369322D structureSCHEMBL606075C19H25N5323.4445 / 23.1Yes
1372252D structureSCHEMBL605178C14H24N6276.3886 / 11.4Yes
1375722D structureSCHEMBL604978C16H26N4O290.4115 / 12.8Yes
1391752D structureCHEMBL492489C14H24N4O264.3735 / 02.5Yes
1405562D structurePF-3893787C13H22N6262.3616 / 31.1Yes
1407132D structureSCHEMBL604462C17H27N5301.4385 / 22.6Yes
1415722D structureCHEMBL494585C14H24N4248.3744 / 12.2Yes
1503532D structureCHEMBL494679C12H22N6250.356 / 11.6Yes
1533702D structureCHEMBL493229C13H19N7273.3446 / 10.1Yes
1549632D structureCHEMBL494724C16H21N5O299.3786 / 11.8Yes
1553722D structureSCHEMBL604979C19H26N6338.4596 / 22.2Yes
1584432D structureCHEMBL492242C14H16F2N6306.3218 / 11.6Yes
1615252D structureCHEMBL493663C12H19N7O277.3326 / 2-0.6Yes
1632622D structureSCHEMBL602901C21H27N5349.4825 / 23.1Yes
1662812D structureSCHEMBL606187C16H25N5287.4115 / 22.3Yes
1680572D structureCHEMBL493478C9H16N6208.2696 / 2-0.6Yes
1697162D structureCHEMBL2376804C14H18N6270.346 / 21.0Yes
1721962D structureCHEMBL502104C15H20N6284.3676 / 22.0Yes
1731402D structureSCHEMBL4054703C22H29N5363.5095 / 23.7Yes
1731412D structureCHEMBL1077276C22H29N5363.5095 / 23.7Yes
1772982D structureCHEMBL523835C14H19N7O301.3548 / 10.4Yes
1777542D structureCHEMBL1089390C17H27N5301.4385 / 22.7Yes
1789492D structureUNII-8U5620H545C17H21N5295.395 / 22.2Yes
1818412D structureCHEMBL523361C21H23N5345.455 / 13.4Yes
1825892D structureCHEMBL492274C16H21N5283.3795 / 12.1Yes
1831312D structureSCHEMBL607364C19H25N5323.4445 / 22.8Yes
1927492D structureSCHEMBL606041C19H25N5323.4445 / 22.9Yes
1940472D structureCHEMBL493104C22H22N6370.466 / 13.1Yes
1961932D structureSCHEMBL606676C19H25N5323.4445 / 22.9Yes
1970722D structureSCHEMBL603530C18H23N5309.4175 / 22.3Yes
2023062D structureCHEMBL494667C12H17N7259.3176 / 20.0Yes
5639852D structureCHEMBL1632411C15H19N3O257.3373 / 22.8Yes
2240772D structureVUF10460C15H19N5269.3525 / 11.8Yes
2242502D structure4-chloro-6-(4-methylpiperazin-1-yl)pyrimidin-2-amineC9H14ClN5227.6965 / 11.1Yes
2258562D structureCHEMBL1092148C18H31N5317.4815 / 23.4Yes
2264822D structureSCHEMBL605565C13H21N5247.3465 / 21.4Yes
2281262D structureCHEMBL492869C14H25N7291.4037 / 10.4Yes
2320872D structurehistamineC5H9N3111.1482 / 2-0.7Yes
2325132D structureCHEMBL494070C21H23N5345.455 / 13.4Yes
2357892D structureCHEMBL592379C21H25ClN6O2S460.9818 / 24.0Yes
2403922D structureCHEMBL448085C12H17N7259.3176 / 10.2Yes
2412552D structureCHEMBL591969C15H21ClN6O2S384.8838 / 22.0Yes
2427842D structureCHEMBL493664C14H18N6O286.3396 / 10.5Yes
2443582D structureCHEMBL452847C18H20ClN5S373.9036 / 14.0Yes
2461872D structureZ-cinnamyl alcoholC9H10O134.1781 / 11.9Yes
2461882D structurecinnamyl alcoholC9H10O134.1781 / 11.9Yes
2483222D structureCHEMBL495280C16H19N7309.3776 / 11.6Yes
2483992D structureCHEMBL493477C10H17N5O223.286 / 10.1Yes
2550332D structureCHEMBL505346C13H17N7271.3287 / 10.1Yes
5545542D structureimetitC6H10N4S170.2343 / 30.2Yes
2668292D structureCHEMBL2376800C13H18N6258.3296 / 20.9Yes
2682372D structureCHEMBL446269C16H19N5281.3635 / 21.7Yes
2737032D structureCHEMBL1078018C17H27N5301.4385 / 22.7Yes
2747902D structureCHEMBL493262C17H19N5293.3745 / 12.1Yes
2760322D structureCHEMBL2376801C14H20N6272.3566 / 21.2Yes
2769612D structureA-846714C16H18N6294.3626 / 11.5Yes

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