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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymH4 receptor
H4R
HH4R
GPCR105
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL495341
Molecular formulaC12H22N4O
IUPAC name4-tert-butyl-6-[2-(dimethylamino)ethoxy]pyrimidin-2-amine
Molecular weight238.335
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP1.9
Synonyms1028327-64-1
4-tert-butyl-6-(2-dimethylaminoethoxy)-pyrimidin-2-ylamine
SCHEMBL2166250
Inchi KeyGGCFHMFNELHSJY-UHFFFAOYSA-N
Inchi IDInChI=1S/C12H22N4O/c1-12(2,3)9-8-10(15-11(13)14-9)17-7-6-16(4)5/h8H,6-7H2,1-5H3,(H2,13,14,15)
PubChem CID25130579
ChEMBLCHEMBL495341
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50302.0 nMPMID18811133ChEMBL
Efficacy67.0 %PMID18811133ChEMBL

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