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Name | Gastrin/cholecystokinin type B receptor |
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Species | Homo sapiens (Human) |
Gene | CCKBR |
Synonym | CCK-B receptor CCK-B receptor {ECO:0000303|PubMed:8415658} CCK-B/gastrin receptor CCK-BR gastrin/cholecystokinin type B receptor [ Show all ] |
Disease | Diagnostic imaging Duodenal ulcers Gastroesophageal reflux disease Gastrointestinal disease Intestine cancer [ Show all ] |
Length | 447 |
Amino acid sequence | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG |
UniProt | P32239 |
Protein Data Bank | N/A |
GPCR-HGmod model | P32239 |
3D structure model | This predicted structure model is from GPCR-EXP P32239. |
BioLiP | N/A |
Therapeutic Target Database | T05849 |
ChEMBL | CHEMBL298 |
IUPHAR | 77 |
DrugBank | BE0001158 |
Name | CHEMBL476095 |
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Molecular formula | C28H26Cl2N4O2 |
IUPAC name | [4-(3,4-dichlorophenyl)piperazin-1-yl]-[1-(3-methoxyphenyl)-2-(4-methylphenyl)imidazol-4-yl]methanone |
Molecular weight | 521.442 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 6.3 |
Synonyms | BDBM50262672 (4-(3,4-dichlorophenyl)piperazin-1-yl)(1-(3-methoxyphenyl)-2-p-tolyl-1H-imidazol-4-yl)methanone |
Inchi Key | BKRZYYKOAAPDMP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H26Cl2N4O2/c1-19-6-8-20(9-7-19)27-31-26(18-34(27)22-4-3-5-23(16-22)36-2)28(35)33-14-12-32(13-15-33)21-10-11-24(29)25(30)17-21/h3-11,16-18H,12-15H2,1-2H3 |
PubChem CID | 44578305 |
ChEMBL | CHEMBL476095 |
IUPHAR | N/A |
BindingDB | 50262672 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
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Activity | 20.0 % | PMID18614364 | ChEMBL |
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