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Name | Muscarinic acetylcholine receptor M2 |
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Species | Homo sapiens (Human) |
Gene | CHRM2 |
Synonym | cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 [ Show all ] |
Disease | Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer [ Show all ] |
Length | 466 |
Amino acid sequence | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR |
UniProt | P08172 |
Protein Data Bank | 5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8 |
GPCR-HGmod model | P08172 |
3D structure model | This structure is from PDB ID 5zkc. |
BioLiP | BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338 |
Therapeutic Target Database | T46185 |
ChEMBL | CHEMBL211 |
IUPHAR | 14 |
DrugBank | BE0000560 |
Name | CHEMBL1202234 |
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Molecular formula | C29H31BrN2O2 |
IUPAC name | (4aR,5aS,8aS,13aS,15aS,15bR)-6-(2-phenylethyl)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-6-ium-14-one;bromide |
Molecular weight | 519.483 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | None |
Synonyms | N-Phenylethyl Strychnine Bromide |
Inchi Key | BLDWBPZYUVTXRR-DBYHAXBSSA-M |
Inchi ID | InChI=1S/C29H31N2O2.BrH/c32-26-17-24-27-21-16-25-29(22-8-4-5-9-23(22)30(26)28(27)29)12-14-31(25,18-20(21)11-15-33-24)13-10-19-6-2-1-3-7-19;/h1-9,11,21,24-25,27-28H,10,12-18H2;1H/q+1;/p-1/t21-,24-,25-,27-,28-,29+,31?;/m0./s1 |
PubChem CID | 10529938 |
ChEMBL | CHEMBL1202234 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Affinity | 5.3 - | PMID9986715 | ChEMBL |
Affinity | 5.7 - | PMID9986715 | ChEMBL |
Cooperativity | <2.0 - | PMID9986715 | ChEMBL |
Cooperativity | >0.2 - | PMID9986715 | ChEMBL |
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