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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesHomo sapiens (Human)
GeneCHRM2
Synonymcholinergic receptor
AChR M2
M2 muscarinic acetylcholine receptor
M2 receptor
Chrm-2
[ Show all ]
DiseaseUrinary incontinence
Heart failure
Nausea; Addiction
Parkinson's disease
Peptic ulcer
[ Show all ]
Length466
Amino acid sequenceMNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP08172
Protein Data Bank5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8
GPCR-HGmod modelP08172
3D structure modelThis structure is from PDB ID 5zkc.
BioLiPBL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338
Therapeutic Target DatabaseT46185
ChEMBLCHEMBL211
IUPHAR14
DrugBankBE0000560

Known ligands

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Total entries: 2910
Page:  / 30 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
2502D structureCHEMBL2426667C28H31N5O453.595 / 02.9Yes
4416812D structureCHEMBL1602658C23H28N2O5S444.5466 / 02.6Yes
5252D structureCHEMBL2407175C24H36N4O3428.5775 / 02.7Yes
8112D structureCHEMBL563305C30H34N2O438.6152 / 15.9No
10202D structureCHEMBL2205816C18H20N2O280.3713 / 11.8Yes
10562D structureCHEMBL466271C32H36BrIN4O6779.477 / 3N/ANo
12782D structureCHEMBL141736C24H29N2O2+377.5082 / 02.8Yes
14132D structureCHEMBL134294C39H65N7O2663.9967 / 34.9No
19412D structureCHEMBL282874C20H20N2O304.3932 / 13.5Yes
22672D structure1-(cyclohexylmethyl)pyrrolidineC11H21N167.2961 / 03.1Yes
23222D structureCHEMBL366819C22H37NO2347.5433 / 05.4No
24182D structureCHEMBL337023C24H33NO4399.5315 / 14.6Yes
29062D structureCHEMBL282680C19H18N2O2306.3653 / 12.6Yes
30652D structureGenostrychnineC21H22N2O3350.4183 / 01.4Yes
31482D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
36402D structureCHEMBL347132C25H32N2O2392.5434 / 13.8Yes
36572D structureCHEMBL23620C23H23N3O3389.4554 / 11.7Yes
38512D structureCEP-11981C28H27N7O477.5725 / 23.9Yes
40062D structureCHEMBL215894C37H41Cl3N4O4712.1095 / 35.9No
41112D structureCHEMBL222634C28H31N4O2+455.5822 / 23.5Yes
49172D structureCHEMBL239657C14H21N2O+233.3352 / 11.8Yes
49872D structureCHEMBL255692C36H46Cl2N2O2609.6764 / 4N/ANo
53552D structureCHEMBL166803C34H56N6O4612.868 / 46.5No
56692D structureAC1L1HUKC29H28ClN3O4518.014 / 25.2No
57522D structureAHOUBRCZNHFOSL-UHFFFAOYSA-NC19H20FNO3329.3715 / 13.5Yes
57692D structureparoxetineC19H20FNO3329.3715 / 13.5Yes
58942D structureCHEMBL73661C28H40N2O2S468.74 / 06.2No
61322D structureCHEMBL237313C23H28BrN2O2+444.3932 / 05.1No
62112D structureCHEMBL294865C36H60N2O4584.8866 / 27.4No
5532742D structureWIN-51708C29H33N3O439.6033 / 16.5No
63212D structureCHEMBL12085C30H35N3O2S501.6894 / 15.4No
63322D structureBDBM86295C12H16N3O2+234.2792 / 00.0Yes
66082D structurecarbacholC6H15ClN2O2182.6483 / 1N/AN/A
66832D structureCHEMBL214029C38H43F3N4O4676.7818 / 34.7No
68352D structureCID 49797317C14H18N2O6310.3068 / 2N/AN/A
68502D structure29712-11-6C21H26ClNO2359.8943 / 1N/AN/A
68842D structureCHEMBL400038C22H26N3O2S+396.5294 / 03.8Yes
4637332D structureCHEMBL3633757C26H24BrNO4494.3855 / 05.4No
71862D structureCHEMBL2024331C23H33N3O3399.5354 / 13.6Yes
72942D structureCHEMBL1779132C26H31BrN2O2S2547.575 / 0N/ANo
74882D structureCHEMBL445134C21H35NO3349.5154 / 14.0Yes
76532D structureCHEMBL84113C14H17NO2231.2953 / 12.5Yes
77772D structureCHEMBL376295C19H25N5O5S2467.55912 / 02.8No
79222D structureCHEMBL432170C29H40F3N5O531.6688 / 05.1No
80222D structureQUININE ACID SULFATEC20H26N2O6S422.4968 / 3N/AN/A
86732D structureCHEMBL1289545C20H24ClN3O2S405.9415 / 03.3Yes
89252D structureCHEMBL513228C25H32N4O5468.5546 / 42.7Yes
89492D structureCHEMBL112208C32H41N5O3543.7126 / 14.0No
91082D structureCHEMBL307554C21H22F2N2O2372.4165 / 32.7Yes
92012D structureCHEMBL519893C30H32N6O4540.6246 / 52.6No
93292D structureCHEMBL521244C31H33N5O5555.6357 / 43.6No
94192D structureCHEMBL170205C21H35NO2333.5163 / 05.0Yes
5479922D structureGlycopyrrolate cationC19H28NO3+318.4373 / 13.1Yes
95312D structureGlycopyrroniumC19H28NO3+318.4373 / 13.1Yes
98622D structureAC-42C20H31NO301.4742 / 05.2No
98982D structureCHEMBL168991C11H16N2O2208.2614 / 00.5Yes
100022D structureCHEMBL358289C26H38F2N2O2448.5995 / 25.7No
100752D structureCHEMBL102749C28H30BrN3O504.4722 / 1N/ANo
101332D structureCHEMBL168304C36H62N4550.924 / 47.6No
101842D structureCHEMBL194206C23H30FN5O2427.5246 / 12.7Yes
103892D structureN-Allyl Brucine IodideC26H31N2O4+435.5444 / 01.6Yes
106892D structureethylestrenolC20H32O288.4751 / 15.1No
107092D structureCHEMBL213709C39H45F3N4O4690.8088 / 25.1No
107482D structureCHEMBL3287723C25H32O7444.5247 / 25.7No
108012D structureDOXACURIUM CHLORIDEC56H78Cl2N2O161106.1418 / 0N/ANo
109122D structureCHEMBL169494C19H22N2278.3992 / 02.4Yes
110092D structureCHEMBL423746C12H16N2O204.2733 / 10.4Yes
113832D structureCHEMBL73410C19H24N2O2S344.4734 / 02.8Yes
5217822D structurepropranololC16H21NO2259.3493 / 23.0Yes
117642D structureCHEMBL556590C19H18ClN3O2355.8224 / 1N/AN/A
119172D structureCHEMBL477821C24H29ClN4O424.9733 / 14.1Yes
120962D structureCHEMBL75108C37H38F2N2O6S676.7769 / 05.9No
121172D structureCHEMBL555173C23H25ClN2O2396.9153 / 1N/AN/A
121192D structureCHEMBL2093910C23H25ClN2O2396.9153 / 1N/AN/A
125422D structureCHEMBL593620C11H24INO2329.2223 / 0N/AN/A
125472D structureCHEMBL593685C11H24INO2329.2223 / 0N/AN/A
125992D structureCHEMBL306903C19H26F2N2O2352.4265 / 32.5Yes
126732D structureCHEMBL343112C21H21BrN2O2413.3153 / 0N/AN/A
127002D structureCHEMBL1083925C20H22ClFN2O360.8573 / 24.3Yes
127522D structureCHEMBL83074C15H16N2O240.3063 / 02.1Yes
128172D structureCHEMBL85190C15H19NO2245.3223 / 03.0Yes
128692D structureSMR000058619C24H34BrN2O4+494.455 / 2N/AN/A
130602D structureCHEMBL397538C16H19N2O2+271.342 / 11.1Yes
131752D structureCHEMBL540148C31H39IN4O6S722.6398 / 5N/ANo
133072D structureAclidiniumC26H30NO4S2+484.6496 / 14.7Yes
137822D structureCHEMBL557808C19H30INO2S463.4184 / 0N/AN/A
142062D structureCHEMBL165035C33H41N3O3S559.7695 / 05.6No
142112D structureCHEMBL122499C35H50N4O4+2590.8094 / 05.0No
142492D structure180083-23-2C32H32N4O3520.6336 / 05.6No
146492D structureCHEMBL1945848C25H28N4O2416.5255 / 03.7Yes
151562D structurecremastrineC14H25NO3255.3584 / 12.2Yes
154292D structureCHEMBL568775C23H32NO2+354.5142 / 14.4Yes
154332D structureCHEMBL569089C23H32NO2+354.5142 / 14.4Yes
154412D structureCHEMBL569307C23H32NO2+354.5142 / 14.4Yes
154422D structureCHEMBL568870C23H32NO2+354.5142 / 14.4Yes
154502D structureCHEMBL569760C23H32NO2+354.5142 / 14.4Yes
154612D structureCHEMBL2205829C19H19NO3309.3654 / 12.2Yes
155532D structureCHEMBL94247C29H38N2O5S3590.8128 / 05.1No
157842D structureCID 44448670C21H28ClNO345.9112 / 2N/AN/A
158302D structureCHEMBL2206602C37H41Cl2N4O5+692.6585 / 46.9No

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