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Name | Type-1 angiotensin II receptor |
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Species | Homo sapiens (Human) |
Gene | AGTR1 |
Synonym | Type-1 angiotensin II receptor HAT1R Agtr-1a type-1A angiotensin II receptor AT1 [ Show all ] |
Disease | Metabolic syndrome x Myocardial infarction Hypertension Restenosis Alzheimer disease [ Show all ] |
Length | 359 |
Amino acid sequence | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE |
UniProt | P30556 |
Protein Data Bank | 6do1, 4zud, 4yay |
GPCR-HGmod model | P30556 |
3D structure model | This structure is from PDB ID 6do1. |
BioLiP | BL0312790, BL0326733, BL0439004,BL0439005 |
Therapeutic Target Database | T74456 |
ChEMBL | CHEMBL227 |
IUPHAR | 34 |
DrugBank | BE0000062 |
Name | losartan |
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Molecular formula | C22H23ClN6O |
IUPAC name | [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol |
Molecular weight | 422.917 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 4.3 |
Synonyms | API0007066 NCGC00095125-05 BRD-K76205745-001-04-1 Q-201321 D0DD0K [ Show all ] |
Inchi Key | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) |
PubChem CID | 3961 |
ChEMBL | CHEMBL191 |
IUPHAR | 3941, 590 |
BindingDB | 82258 |
DrugBank | DB00678 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
Affinity | 6.4 nM | PMID15974591 | ChEMBL |
Emax | 1.0 hr | PMID15974591 | ChEMBL |
IC50 | 0.33 nM | PMID22727371 | BindingDB,ChEMBL |
IC50 | 1.99 - 39.8 nM | PMID8372104 | IUPHAR |
IC50 | 3.2 nM | PMID27480029 | BindingDB |
IC50 | 3.236 nM | PMID27480029 | ChEMBL |
IC50 | 5.62 nM | PMID22889560 | BindingDB |
IC50 | 5.623 nM | PMID22889560, PMID23376252 | ChEMBL |
IC50 | 6.0 nM | PMID22889560 | BindingDB,ChEMBL |
IC50 | 8.0 nM | Bioorg. Med. Chem. Lett., (1994) 4:1:29 | ChEMBL |
IC50 | 16.2 nM | PMID22309912, MedChemComm, (2015) 6:8:1479, PMID22727371, PMID24007859 | BindingDB,ChEMBL |
IC50 | 28.0 nM | PMID14761190 | ChEMBL |
IC50 | 28.6 nM | PMID26397395 | ChEMBL |
IC50 | 88.0 nM | PMID7562905 | ChEMBL |
Kb | 4.0 nM | PMID16610806 | ChEMBL |
Kb | 5.0 nM | PMID15509155 | ChEMBL |
Kb | 9.0 nM | PMID16610806 | ChEMBL |
Kd | 3.311 nM | PMID21071232 | ChEMBL |
Ki | 12.0 nM | PMID26824643 | BindingDB,ChEMBL |
Ki | 17.0 nM | PMID26824643 | BindingDB,ChEMBL |
pKa | 4.9 - | PMID15974591 | ChEMBL |
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