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Name | Muscarinic acetylcholine receptor M1 |
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Species | Homo sapiens (Human) |
Gene | CHRM1 |
Synonym | cholinergic receptor cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS Chrm-1 M1 receptor [ Show all ] |
Disease | Functional bowel syndrome; Irritable bowel syndrome Glaucoma Peptic ulcer Parkinsonism; Extrapyramidal disorders secondary to neuroleptic drug therapy Visceral spasms [ Show all ] |
Length | 460 |
Amino acid sequence | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC |
UniProt | P11229 |
Protein Data Bank | 5cxv |
GPCR-HGmod model | P11229 |
3D structure model | This structure is from PDB ID 5cxv. |
BioLiP | BL0339262, BL0339261, BL0339263 |
Therapeutic Target Database | T28893 |
ChEMBL | CHEMBL216 |
IUPHAR | 13 |
DrugBank | BE0000092 |
Name | CHEMBL315428 |
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Molecular formula | C14H16N2O4 |
IUPAC name | 8-azabicyclo[3.2.1]octan-6-yl 4-nitrobenzoate |
Molecular weight | 276.292 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 2.3 |
Synonyms | 4-Nitro-benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester BDBM50089791 |
Inchi Key | BMBATQJOKULRPS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C14H16N2O4/c17-14(9-4-6-11(7-5-9)16(18)19)20-13-8-10-2-1-3-12(13)15-10/h4-7,10,12-13,15H,1-3,8H2 |
PubChem CID | 44318736 |
ChEMBL | CHEMBL315428 |
IUPHAR | N/A |
BindingDB | 50089791 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 29.0 nM | PMID10891110 | BindingDB,ChEMBL |
Ki | 780.0 nM | PMID10891110 | BindingDB |
Ki | 780.0 nM | PMID10891110 | ChEMBL |
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