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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMuscarinic acetylcholine receptor M1
SpeciesHomo sapiens (Human)
GeneCHRM1
Synonymcholinergic receptor
cholinergic receptor, muscarinic 1
cholinergic receptor, muscarinic 1, CNS
Chrm-1
M1 receptor
[ Show all ]
DiseaseFunctional bowel syndrome; Irritable bowel syndrome
Glaucoma
Peptic ulcer
Parkinsonism; Extrapyramidal disorders secondary to neuroleptic drug therapy
Visceral spasms
[ Show all ]
Length460
Amino acid sequenceMNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProtP11229
Protein Data Bank5cxv
GPCR-HGmod modelP11229
3D structure modelThis structure is from PDB ID 5cxv.
BioLiPBL0339262, BL0339261, BL0339263
Therapeutic Target DatabaseT28893
ChEMBLCHEMBL216
IUPHAR13
DrugBankBE0000092

Known ligands

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Total entries: 3808
Page:  / 39 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
1312D structureCHEMBL140142C26H40N6O6S2596.76214 / 01.0No
1562D structureCHEMBL2057501C18H20F3N5O3S2475.50511 / 01.5No
2192D structureCHEMBL1800884C24H23N3O3401.4665 / 10.8Yes
4416782D structureCHEMBL1602658C23H28N2O5S444.5466 / 02.6Yes
3012D structureCHEMBL341379C8H13FN2O172.2034 / 01.0Yes
5359202D structureCHEMBL3983937C22H27N5OS409.5526 / 03.3Yes
5232D structureCHEMBL2407175C24H36N4O3428.5775 / 02.7Yes
7362D structureCHEMBL2058899C20H21F3N4O4S470.46710 / 02.0Yes
7632D structureCHEMBL1090526C20H24FN3O341.435 / 02.7Yes
8122D structureCHEMBL563305C30H34N2O438.6152 / 15.9No
10042D structureCHEMBL2205816C18H20N2O280.3713 / 11.8Yes
10542D structureCHEMBL466271C32H36BrIN4O6779.477 / 3N/ANo
11872D structureCHEMBL2059319C24H27FN4O2422.5044 / 13.9Yes
12772D structureCHEMBL141736C24H29N2O2+377.5082 / 02.8Yes
19402D structureCHEMBL282874C20H20N2O304.3932 / 13.5Yes
22642D structure1-(cyclohexylmethyl)pyrrolidineC11H21N167.2961 / 03.1Yes
23212D structureCHEMBL366819C22H37NO2347.5433 / 05.4No
29082D structureCHEMBL282680C19H18N2O2306.3653 / 12.6Yes
30632D structureGenostrychnineC21H22N2O3350.4183 / 01.4Yes
31352D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
31782D structureCHEMBL600482C22H14F2N2O3392.3627 / 14.3Yes
5573782D structureSCHEMBL18211801C27H26FN3O3459.5215 / 23.8Yes
34152D structureCHEMBL1683363C19H20N4O3352.3945 / 2-0.7Yes
34232D structureCHEMBL2057492C19H21FN4O3S404.467 / 00.9Yes
34702D structureCHEMBL2333480C27H28F2N4O462.5455 / 03.9Yes
35512D structureCHEMBL2312348C22H25NO3351.4464 / 03.1Yes
36392D structureCHEMBL347132C25H32N2O2392.5434 / 13.8Yes
36552D structureCHEMBL23620C23H23N3O3389.4554 / 11.7Yes
40092D structureCHEMBL215894C37H41Cl3N4O4712.1095 / 35.9No
43212D structuresulconazoleC18H15Cl3N2S397.7422 / 06.1No
44142D structureCHEMBL2377264C19H29NO2S335.5064 / 04.8Yes
49692D structureCHEMBL1243232C19H27N3O3345.4434 / 11.8Yes
49852D structureCHEMBL255692C36H46Cl2N2O2609.6764 / 4N/ANo
57422D structureAHOUBRCZNHFOSL-UHFFFAOYSA-NC19H20FNO3329.3715 / 13.5Yes
57572D structureparoxetineC19H20FNO3329.3715 / 13.5Yes
58932D structureCHEMBL73661C28H40N2O2S468.74 / 06.2No
61312D structureCHEMBL237313C23H28BrN2O2+444.3932 / 05.1No
61922D structureCHEMBL1090186C21H27N3O2353.4665 / 02.5Yes
62492D structureWIN-51708C29H33N3O439.6033 / 16.5No
64822D structureCHEMBL272359C13H22N4OS282.4066 / 11.2Yes
66102D structurecarbacholC6H15ClN2O2182.6483 / 1N/AN/A
66812D structureCHEMBL214029C38H43F3N4O4676.7818 / 34.7No
68312D structureCHEMBL1940120C19H22N6O3S2446.5449 / 11.1Yes
68332D structureCID 49797317C14H18N2O6310.3068 / 2N/AN/A
68832D structureCHEMBL400038C22H26N3O2S+396.5294 / 03.8Yes
4637352D structureCHEMBL3633757C26H24BrNO4494.3855 / 05.4No
71852D structureCHEMBL2024329C23H33N3O3399.5354 / 13.6Yes
71882D structureCHEMBL2024331C23H33N3O3399.5354 / 13.6Yes
72962D structureCHEMBL1779132C26H31BrN2O2S2547.575 / 0N/ANo
74142D structureCHEMBL2042688C21H21N3O3363.4175 / 10.3Yes
74872D structureCHEMBL445134C21H35NO3349.5154 / 14.0Yes
76542D structureCHEMBL84113C14H17NO2231.2953 / 12.5Yes
77792D structureCHEMBL376295C19H25N5O5S2467.55912 / 02.8No
79232D structureCHEMBL432170C29H40F3N5O531.6688 / 05.1No
79772D structureCHEMBL600419C21H15FN2O3362.365 / 14.0Yes
85732D structureCHEMBL97235C16H22ClN2O+293.8151 / 02.1Yes
86742D structureCHEMBL1084807C19H23ClN2O2S378.9154 / 13.6Yes
88162D structureCHEMBL2164906C20H24N2O308.4252 / 03.1Yes
88172D structureCHEMBL2164911C20H24N2O308.4252 / 03.1Yes
89262D structureCHEMBL513228C25H32N4O5468.5546 / 42.7Yes
91072D structureCHEMBL307554C21H22F2N2O2372.4165 / 32.7Yes
92022D structureCHEMBL519893C30H32N6O4540.6246 / 52.6No
93312D structureCHEMBL521244C31H33N5O5555.6357 / 43.6No
94202D structureCHEMBL170205C21H35NO2333.5163 / 05.0Yes
5479912D structureGlycopyrrolate cationC19H28NO3+318.4373 / 13.1Yes
95342D structureGlycopyrroniumC19H28NO3+318.4373 / 13.1Yes
96502D structureCHEMBL596211C23H17FN2O4404.3977 / 14.4Yes
97202D structureCHEMBL2313495C22H24N4O360.4613 / 02.7Yes
4420892D structureCHEMBL3414838C30H34BrFN4O4613.5288 / 1N/ANo
98572D structureAC-42C20H31NO301.4742 / 05.2No
98992D structureCHEMBL168991C11H16N2O2208.2614 / 00.5Yes
100032D structureCHEMBL358289C26H38F2N2O2448.5995 / 25.7No
101772D structureCHEMBL194206C23H30FN5O2427.5246 / 12.7Yes
102862D structuredoxorubicinC27H29NO11543.52512 / 61.3No
103882D structureN-Allyl Brucine IodideC26H31N2O4+435.5444 / 01.6Yes
104622D structureCHEMBL1771699C20H17FN2O3352.3656 / 13.7Yes
106232D structureSCHEMBL2145822C17H12ClNO3313.7373 / 13.7Yes
107072D structureCHEMBL213709C39H45F3N4O4690.8088 / 25.1No
107202D structureCHEMBL3287723C25H32O7444.5247 / 25.7No
108272D structureCHEMBL2058897C19H20N6O3S2444.5289 / 00.7Yes
109132D structureCHEMBL169494C19H22N2278.3992 / 02.4Yes
110082D structureCHEMBL423746C12H16N2O204.2733 / 10.4Yes
111822D structureISOCLOZAPINEC18H19ClN4326.8283 / 13.1Yes
113842D structureCHEMBL73410C19H24N2O2S344.4734 / 02.8Yes
5217882D structurepropranololC16H21NO2259.3493 / 23.0Yes
117632D structureCHEMBL556590C19H18ClN3O2355.8224 / 1N/AN/A
117812D structureCHEMBL521388C25H26ClF3N4O2506.9546 / 14.6No
119152D structureCHEMBL477821C24H29ClN4O424.9733 / 14.1Yes
119902D structureCHEMBL2313512C19H16FN3O2337.3544 / 02.6Yes
121182D structureCHEMBL555173C23H25ClN2O2396.9153 / 1N/AN/A
4643672D structureCHEMBL3600817C30H34FN3O2487.6195 / 24.6Yes
124222D structureCHEMBL1771772C20H16FNO3337.355 / 14.6Yes
125432D structureCHEMBL593620C11H24INO2329.2223 / 0N/AN/A
125482D structureCHEMBL593685C11H24INO2329.2223 / 0N/AN/A
125972D structureCHEMBL306903C19H26F2N2O2352.4265 / 32.5Yes
126742D structureCHEMBL343112C21H21BrN2O2413.3153 / 0N/AN/A
127012D structureCHEMBL1083925C20H22ClFN2O360.8573 / 24.3Yes
127052D structureCHEMBL1083926C20H22ClFN2O360.8573 / 24.3Yes
127252D structureCHEMBL1940135C19H22N6O4S430.4839 / 10.5Yes
127512D structureCHEMBL83074C15H16N2O240.3063 / 02.1Yes

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