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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	P2Y purinoceptor 14
Species	Homo sapiens (Human)
Gene	P2RY14
Synonym	G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y G protein coupled receptor for UDP-glucose UDP-glucose receptor [ Show all ]
Disease	N/A
Length	338
Amino acid sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProt	Q15391
Protein Data Bank	N/A
GPCR-HGmod model	Q15391
3D structure model	This predicted structure model is from GPCR-EXP Q15391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4518
IUPHAR	330
DrugBank	N/A

Ligand

Name	P1-uridyl-P2-methyl diphosphate
Molecular formula	C10H14N2O12P2-2
IUPAC name	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] methyl phosphate
Molecular weight	416.172
Hydrogen bond acceptor	12
Hydrogen bond donor	3
XlogP	-4.3
Synonyms	BDBM50303341 Diphosphoric Acid 1-beta-Methyl Ester 2-(Uridine-5''-yl)ester, di ammonium Salt
Inchi Key	QEXWQSCECHIMQL-ZOQUXTDFSA-L
Inchi ID	InChI=1S/C10H16N2O12P2/c1-21-25(17,18)24-26(19,20)22-4-5-7(14)8(15)9(23-5)12-3-2-6(13)11-10(12)16/h2-3,5,7-9,14-15H,4H2,1H3,(H,17,18)(H,19,20)(H,11,13,16)/p-2/t5-,7-,8-,9-/m1/s1
PubChem CID	25202179
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50303341
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2730.0 nM	PMID19902968	BindingDB

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