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Name | Glucagon receptor |
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Species | Homo sapiens (Human) |
Gene | GCGR |
Synonym | GL-R GGR GR glucagon receptor |
Disease | Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes [ Show all ] |
Length | 477 |
Amino acid sequence | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF |
UniProt | P47871 |
Protein Data Bank | 5yqz, 5xez, 5ee7, 5xf1 |
GPCR-HGmod model | P47871 |
3D structure model | This structure is from PDB ID 5yqz. |
BioLiP | BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437 |
Therapeutic Target Database | T60182, T87875 |
ChEMBL | CHEMBL1985 |
IUPHAR | 251 |
DrugBank | N/A |
Name | CHEMBL453457 |
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Molecular formula | C31H32F3N3O5S |
IUPAC name | (2R)-3-[[4-[[4-cyclohexyl-N-[[4-(trifluoromethylsulfanyl)phenyl]carbamoyl]anilino]methyl]benzoyl]amino]-2-hydroxypropanoic acid |
Molecular weight | 615.668 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 4 |
XlogP | 6.6 |
Synonyms | BDBM50245060 SCHEMBL2654359 |
Inchi Key | REIGIHUHXDNPSA-HHHXNRCGSA-N |
Inchi ID | InChI=1S/C31H32F3N3O5S/c32-31(33,34)43-26-16-12-24(13-17-26)36-30(42)37(25-14-10-22(11-15-25)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)28(39)35-18-27(38)29(40)41/h6-17,21,27,38H,1-5,18-19H2,(H,35,39)(H,36,42)(H,40,41)/t27-/m1/s1 |
PubChem CID | 10167904 |
ChEMBL | CHEMBL453457 |
IUPHAR | N/A |
BindingDB | 50245060 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 6.0 nM | PMID18707090 | BindingDB,ChEMBL |
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