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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	3-Chloro-5-hydroxybenzoic acid
Molecular formula	C7H5ClO3
IUPAC name	3-chloro-5-hydroxybenzoic acid
Molecular weight	172.564
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.8
Synonyms	4CH-024347 AJ-43876 Benzoic acid,3-chloro-5-hydroxy- FT-0650742 SBB052708 ZINC2599133 3-chloranyl-5-oxidanyl-benzoic acid 984C364 AM84171 CL8082 KB-31117 ST24042056 3-Chloro-5-hydroxybenzoic acid, >=97% (HPLC) AB18080 BDBM50391825 DTXSID50517335 MolPort-009-196-828 TS-02354 AK107678 I01-11521 SC-73033 3-CHLORO-5-HYDROXY-BENZOIC ACID A829885 AN-40681 CTK4J9210 KS-00000K5A SY025109 3-hydroxy-5-chlorobenzoic acid ACMC-209lbs Benzoic acid, 3-chloro-5-hydroxy- FT-0080917 RJOLIYHZZKAIET-UHFFFAOYSA-N X8059 53984-36-4 AKOS006293910 CHEMBL2146910 K-9757 SCHEMBL1999585 AB0033979 ANW-31910 DB-006403 MFCD04114327 TC-120655 [ Show all ]
Inchi Key	RJOLIYHZZKAIET-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H5ClO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9H,(H,10,11)
PubChem CID	13071646
ChEMBL	CHEMBL2146910
IUPHAR	N/A
BindingDB	50391825
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID24900524	BindingDB,ChEMBL

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