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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL39623
Molecular formula	C20H26ClN3O2
IUPAC name	4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-phenylmethoxybenzamide
Molecular weight	375.897
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.1
Synonyms	AC1Q3QFW 4-Amino-2-benzyloxy-5-chloro-N-(2-diethylamino-ethyl)-benzamide N-(Diethylaminoethyl)-2-benzyloxy-4-amino-5-chlorobenzamide BDBM50023805 23205-22-3 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-(phenylmethoxy)benzamide AC1L4QW4 Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-(phenylmethoxy)- 4-amino-2-(benzyloxy)-5-chloro-n-[2-(diethylamino)ethyl]benzamide LS-25422 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-phenylmethoxybenzamide [ Show all ]
Inchi Key	RNDGARWUQSIOQW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H26ClN3O2/c1-3-24(4-2)11-10-23-20(25)16-12-17(21)18(22)13-19(16)26-14-15-8-6-5-7-9-15/h5-9,12-13H,3-4,10-11,14,22H2,1-2H3,(H,23,25)
PubChem CID	211484
ChEMBL	CHEMBL39623
IUPHAR	N/A
BindingDB	50023805
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	<40.0 mg.kg-1	PMID3397992	ChEMBL
IC50	<1000.0 nM	PMID3397992	BindingDB,ChEMBL

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