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Name | Endothelin receptor type B |
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Species | Homo sapiens (Human) |
Gene | EDNRB |
Synonym | endothelin B receptor HSCR2 HSCR ETB receptor ET-BR [ Show all ] |
Disease | Arrhythmia Hypertension Pulmonary arterial hypertension Solid tumours Cancer [ Show all ] |
Length | 442 |
Amino acid sequence | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS |
UniProt | P24530 |
Protein Data Bank | 6igl, 6igk, 5xpr, 5x93 |
GPCR-HGmod model | P24530 |
3D structure model | This structure is from PDB ID 6igl. |
BioLiP | BL0388813, BL0433639, BL0433638, BL0388896, BL0388814 |
Therapeutic Target Database | T92828 |
ChEMBL | CHEMBL1785 |
IUPHAR | 220 |
DrugBank | BE0000043 |
Name | CHEMBL288967 |
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Molecular formula | C18H15BrF3N3O7S2 |
IUPAC name | 3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(3-methoxyphenyl)thiophene-2-carboxamide;2,2,2-trifluoroacetic acid |
Molecular weight | 586.351 |
Hydrogen bond acceptor | 13 |
Hydrogen bond donor | 3 |
XlogP | None |
Synonyms | N/A |
Inchi Key | BTAFWGRLTJPHAZ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H14BrN3O5S2.C2HF3O2/c1-9-13(17)16(25-19-9)20-27(22,23)12-6-7-26-14(12)15(21)18-10-4-3-5-11(8-10)24-2;3-2(4,5)1(6)7/h3-8,20H,1-2H3,(H,18,21);(H,6,7) |
PubChem CID | 44291725 |
ChEMBL | CHEMBL288967 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 63100.0 nM | PMID9171877 | ChEMBL |
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