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GLASS

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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	n-Propylapomorphine
Molecular formula	C19H21NO2
IUPAC name	(6aR)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
Molecular weight	295.382
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.2
Synonyms	BDBM50012994 CHEMBL538542 PDSP1_000853 SKF-76783 (9R)-10-propyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,13,15-hexaene-3,4-diol 6-Propylnoraporphine-10,11-diol BRD-K13544237-001-01-0 D-027 N-propylnorapomorphine-(-) PDSP2_000840 ZINC2539817 (-)-6-Propylnorapomorphine (R)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol AC1Q7BE4 GTPL969 Noraporphine-10,11-diol, 6-propyl- R-N-PROPYLNORAPOMORPHINE (-)-NPA 4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-propyl-, (6aR)- 6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol Biomol-NT_000080 cid_11957529 N-Propylnorapomorphine PDSP1_001509 UNII-NH381P1BR8 (+)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol (R) 6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol CCG-204527 D06DGY NCGC00162153-03 PDSP2_001493 (-)-N-porphynorapomorphine 10,11-Dihydroxy-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium(R(-)NPA) BDBM50007422 CHEMBL225230 Lopac0_000435 PDSP1_000852 SCHEMBL7997518 (6ar)-6-propyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol 6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol; hydrochloride BPBio1_001404 CTK4D8694 N-propylnorapomorphine-(+) PDSP2_000839 Win-28928 (-)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol (R)-10,11-Dihydroxy-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium AC1L50G2 CHEBI:92234 D07XYQ NH381P1BR8 r(-)-10,11-dihydroxy-N-n-propylnoraporphine (-)-N-Propylnorapomorphine 18426-20-5 [ Show all ]
Inchi Key	BTGAJCKRXPNBFI-OAHLLOKOSA-N
Inchi ID	InChI=1S/C19H21NO2/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14/h3-7,15,21-22H,2,8-11H2,1H3/t15-/m1/s1
PubChem CID	167715
ChEMBL	CHEMBL225230
IUPHAR	969
BindingDB	50012994, 50007422
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.8 nM	PMID2147956	BindingDB,ChEMBL
IC50	10.0 nM	PMID2968456	BindingDB,ChEMBL
Kd	9.0 nM	PMID10956209	BindingDB,ChEMBL
Kd	40.0 nM	PMID10956209	BindingDB,ChEMBL
Kd	370.0 nM	PMID10956209	BindingDB,ChEMBL
Kd	520.0 nM	PMID10956209	BindingDB,ChEMBL
Ki	<10000.0 nM	PMID9021894	BindingDB
Ki	0.18 nM	PMID21666830	BindingDB,ChEMBL
Ki	0.8 nM	PMID2136919, PMID1671415	BindingDB
Ki	0.8 nM	PMID1971309, PMID1671415	BindingDB,ChEMBL
Ki	0.9 nM	PMID18251489	ChEMBL
Ki	10.0 nM	PMID17228858	BindingDB,ChEMBL
Ki	54.0 nM	PMID21666830	BindingDB,ChEMBL
Ki	460.0 nM	PMID9021894	BindingDB
KL	23.0 nM	PMID8632409	ChEMBL

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