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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Homo sapiens (Human)
Gene	HTR1D
Synonym	Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D 5-HT-1D-alpha 5-HT1D 5-HT1D receptor 5-HT1Dalpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Gpcr14 HT1DA [ Show all ]
Disease	Acute migraine Epilepsy Migraine headaches Mood disorder Migraine Major depressive disorder Severe mood disorders [ Show all ]
Length	377
Amino acid sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProt	P28221
Protein Data Bank	N/A
GPCR-HGmod model	P28221
3D structure model	This predicted structure model is from GPCR-EXP P28221.
BioLiP	N/A
Therapeutic Target Database	T11072
ChEMBL	CHEMBL1983
IUPHAR	3
DrugBank	BE0000659

Ligand

Name	metoclopramide
Molecular formula	C14H22ClN3O2
IUPAC name	4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
Molecular weight	299.799
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.6
Synonyms	Metaclopramide Neu-Sensamide Cerucal Metochloropramide Parmid Clopromate (metoclopramide)4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide Pramiel DEL 1267 2576-84-3 (di-hydrochloride) Primperan (TN) Elieten 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide SBB037841 Gastro-Timelets 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide Spectrum4_000964 GTPL241 AB00053498 Tox21_110188 KBio1_000069 Metoclopramidum AN-44542 KS-00000GNS N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide Benzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy- Maxeran NCGC00015643-07 BRN 1884366 Metamide o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- CHEMBL86 Peraprin D00726 2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethyl)benzamide Prestwick1_000209 DSSTox_GSID_45169 4 Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Regla Emitasol 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide(Metoclopramide) SCHEMBL18629 Gastronerton 4-azanyl-5-chloranyl-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride ST024773 HY-17382 Metoclopramide Monohydrochloride, Monohydrate AB1009457 UNII-L4YEB44I46 KBio2_007254 Metramid BDBM48320 L001078 NCGC00015643-02 BPBio1_000217 Maxolon (Salt/Mix) NCGC00015643-11 C07868 NCGC00024440-04 CAS-7232-21-5 Methoxychlorprocainamide o-Anisamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]- CLOPRA-"YELLOW" (4-amino-5-chloro-2-methoxyphenyl)-N-[2-(diethylamino)ethyl]carboxamide Pms-Metoclopramide DB01233 232M215 Primperan Duraclamid 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Reglan (TN) FT-0628931 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide Spectrum2_001720 Gastrotem Metoclopramida 54143-57-6 (mono-hydrochloride, mono-hydrate) Terperan J90028 Metoclopramide, European Pharmacopoeia (EP) Reference Standard AK468880 ZINC1530716 KBioSS_002118 Mygdalon Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-(9CI) Lopac0_000762 NCGC00015643-05 BRD-K75641298-003-05-2 Meclopran Metaclopromide NINDS_000069 CHEBI:107736 Paspertin CS-1064 Pramin DivK1c_000069 364-62-5 Pylomid (TN) Elieten (TN) 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide (Mcp) SBI-0050740.P004 Gastrobid 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide; Methoxychloroprocainamide Spectrum5_001449 HMS2089G16 Metoclopramide (JP15/INN) AB00053498-13 Tox21_110188_1 KBio2_002118 Metoclopramidum [INN-Latin] Apo-Metoclop KS-000048I1 n-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- Biomol-NT_000082 Maxeran (TN) NCGC00015643-08 BSPBio_000197 C14H22ClN3O2 Methochlopramide o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- (8CI) cid_23659 Plasil D08VYV 2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethylbenzamide Prestwick2_000209 DSSTox_RID_80719 4-Amino-5-chloro-2-methoxy-N-(.beta.-diethylaminoethyl)benzamide Reglan Emperal 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide SPBio_001740 Gastrosil ST077151 IDI1_000069 Metoclopramide Omega AC1L1HKD US9132134, Metoclopramide KBio3_001527 MolPort-000-883-854 Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy- L4YEB44I46 NCGC00015643-03 BPBio1_001100 Maxolon (TN) NCGC00015643-13 NCI60_003185 CCG-204847 Metochlopramide Octamide Clopra-Yellow (metaclopramide)4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide Pramidin Degan (TN) Primperan (tablet) (Salt/Mix) EINECS 206-662-9 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide Reliveran Gastrese 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride Spectrum3_000504 Gimoli Metoclopramida [INN-Spanish] 7232-21-5 (mono-hydrochloride) Terperan (TN) KB-189202 Metoclopramide, VETRANAL(TM), analytical standard AKOS000280832 KM1470 N-(2-diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy- LS-20038 NCGC00015643-06 BRD-K75641298-003-16-9 Megaldrate Metadrate Nu-Metoclopramide Paspertin (Salt/Mix) CTK8G1095 2-methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide Prestwick0_000209 DSSTox_CID_25169 364M625 Reclomide Emetid 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide (metoclopramide) SC-81367 Gastromax 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride Spectrum_001638 HSDB 7841 Metoclopramide (JP17/INN) AB00053498_14 TTWJBBZEZQICBI-UHFFFAOYSA-N KBio2_004686 Metocobil ARONIS24307 KS-5055 NCGC00015643-01 bmse000779 Maxolon NCGC00015643-09 BSPBio_002027 NCGC00024440-03 CAS-364-62-5 Methoclopramide O-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-(8CI) Clopra Plasil (pharmaceutical) 2-Methoxy-5-chloroprocainamide Prestwick3_000209 DTXSID6045169 4-Amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide Reglan (Salt/Mix) Eucil 4-amino-5-chloro-N-[2-(diethylamino)-ethyl]-2-methoxybenzamide SPBio_002118 Gastrotablinen Metoclol 5-Chloro-2-methoxyprocainamide STL257058 Imperan Metoclopramide [INN:BAN:JAN] AJ-26684 Z2196779550 KBioGR_001307 Moriperan Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy- (9CI) Lopac-M-0763 NCGC00015643-04 BRD-K75641298-001-01-5 MCULE-8566255889 [ Show all ]
Inchi Key	TTWJBBZEZQICBI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
PubChem CID	4168
ChEMBL	CHEMBL86
IUPHAR	241
BindingDB	48320
DrugBank	DB01233
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	Peroutka et al., PMID1989	PDSP

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