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Name | Glucagon receptor |
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Species | Homo sapiens (Human) |
Gene | GCGR |
Synonym | GL-R GGR GR glucagon receptor |
Disease | Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes [ Show all ] |
Length | 477 |
Amino acid sequence | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF |
UniProt | P47871 |
Protein Data Bank | 5yqz, 5xez, 5ee7, 5xf1 |
GPCR-HGmod model | P47871 |
3D structure model | This structure is from PDB ID 5yqz. |
BioLiP | BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437 |
Therapeutic Target Database | T60182, T87875 |
ChEMBL | CHEMBL1985 |
IUPHAR | 251 |
DrugBank | N/A |
Name | CHEMBL1644188 |
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Molecular formula | C27H19F6N7O3 |
IUPAC name | 4-[1-[3,5-bis[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]ethyl]-N-(2H-tetrazol-5-yl)benzamide |
Molecular weight | 603.485 |
Hydrogen bond acceptor | 13 |
Hydrogen bond donor | 2 |
XlogP | 6.6 |
Synonyms | BDBM50334484 SCHEMBL12360171 4-(1-(3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyrazol-1-yl)ethyl)-N-(2H-tetrazol-5-yl)benzamide |
Inchi Key | UCXDATDHRBYGIQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H19F6N7O3/c1-15(16-2-4-19(5-3-16)24(41)34-25-35-38-39-36-25)40-23(18-8-12-21(13-9-18)43-27(31,32)33)14-22(37-40)17-6-10-20(11-7-17)42-26(28,29)30/h2-15H,1H3,(H2,34,35,36,38,39,41) |
PubChem CID | 10077369 |
ChEMBL | CHEMBL1644188 |
IUPHAR | N/A |
BindingDB | 50334484 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 130.0 nM | PMID21147532 | BindingDB,ChEMBL |
IC50 | 1300.0 nM | PMID21147532 | BindingDB,ChEMBL |
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