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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Mu-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprm1
Synonym	Opioid receptor B opioid receptor OP3 mu receptor MOR-1 MOPr MOP M-OR-1 opioid receptor, mu 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P33535
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL270
IUPHAR	319
DrugBank	N/A

Ligand

Name	Leu-enkephalin
Molecular formula	C28H37N5O7
IUPAC name	(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-azaniumyl-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoate
Molecular weight	555.632
Hydrogen bond acceptor	7
Hydrogen bond donor	6
XlogP	-0.5
Synonyms	N/A
Inchi Key	URLZCHNOLZSCCA-VABKMULXSA-N
Inchi ID	InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1
PubChem CID	124081685
ChEMBL	CHEMBL8234
IUPHAR	N/A
BindingDB	50001465
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	49.8 nM	PMID6296388	ChEMBL
IC50	50.0 nM	PMID6296388	BindingDB
Ki	1.22 nM	PMID2537427	BindingDB
Ki	2.21 nM	PMID6296388	BindingDB
Ki	2.4 nM	PMID11212102	BindingDB
Ki	2.42 nM	PMID11212102	ChEMBL
Ki	2.53 nM	PMID10691681	ChEMBL
Ki	9.4 nM	PMID10479285, PMID2536436, PMID8230106, PMID8164255, PMID1331451	BindingDB
Ki	9.43 nM	PMID2536436, PMID1331451, PMID2999401, PMID20218625, PMID10479285, PMID2537427, PMID8164255, PMID8230106	ChEMBL
Ki	9.6 nM	PMID2999401	BindingDB
Ki	24.0 nM	PMID12372527	BindingDB,ChEMBL
Ki	27.7 nM	PMID6296388	ChEMBL
Potency	1.0 -	PMID8230106	ChEMBL
Potency ratio	1.0 -	PMID2999401	ChEMBL
Ratio	3.73 -	PMID10479285	ChEMBL
Relative potency	1.0 -	PMID10479285, PMID2537427, PMID8164255, PMID1331451	ChEMBL
SR	1.69 -	PMID11212102	ChEMBL

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