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Name | Histamine H4 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH4 |
Synonym | Pfi-013 SP9144 HH4R H4R H4 receptor [ Show all ] |
Disease | Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis |
Length | 390 |
Amino acid sequence | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS |
UniProt | Q9H3N8 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9H3N8 |
3D structure model | This predicted structure model is from GPCR-EXP Q9H3N8. |
BioLiP | N/A |
Therapeutic Target Database | T26500 |
ChEMBL | CHEMBL3759 |
IUPHAR | 265 |
DrugBank | BE0000146 |
Name | CHEMBL1077636 |
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Molecular formula | C12H20N6 |
IUPAC name | 1-cyano-2-[4-(1H-imidazol-5-yl)butyl]-3-propan-2-ylguanidine |
Molecular weight | 248.334 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 3 |
XlogP | 1.2 |
Synonyms | 2-Cyano-1-[4-(1H-imidazol-4-yl)butyl]-3-isopropylguanidine 1192560-03-4 BDBM50415659 |
Inchi Key | BWNYFRHMGXLSFD-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H20N6/c1-10(2)18-12(16-8-13)15-6-4-3-5-11-7-14-9-17-11/h7,9-10H,3-6H2,1-2H3,(H,14,17)(H2,15,16,18) |
PubChem CID | 44480960 |
ChEMBL | CHEMBL1077636 |
IUPHAR | N/A |
BindingDB | 50415659 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 331.13 nM | PMID19791743 | BindingDB,ChEMBL |
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