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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameHistamine H4 receptor
SpeciesHomo sapiens (Human)
GeneHRH4
SynonymPfi-013
SP9144
HH4R
H4R
H4 receptor
[ Show all ]
DiseaseAllergic rhinitis
Asthma
Inflammatory disease
Rheumatoid arthritis
Length390
Amino acid sequenceMPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProtQ9H3N8
Protein Data BankN/A
GPCR-HGmod modelQ9H3N8
3D structure modelThis predicted structure model is from GPCR-EXP Q9H3N8.
BioLiPN/A
Therapeutic Target DatabaseT26500
ChEMBLCHEMBL3759
IUPHAR265
DrugBankBE0000146

Known ligands

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Total entries: 1810
Page:  / 19 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
762D structureSCHEMBL602163C26H35ClN4O455.0434 / 16.0No
2292D structureCHEMBL3236571C13H23N5249.3625 / 21.8Yes
3752D structureCHEMBL1078529C16H20N6S328.4384 / 32.2Yes
5322D structureCHEMBL1915037C15H13Cl2N5O350.2036 / 23.0Yes
10112D structureCHEMBL2205816C18H20N2O280.3713 / 11.8Yes
5214822D structureCHEMBL3806146C14H20N6272.3563 / 31.7Yes
5214852D structureCHEMBL3804837C14H20N6272.3563 / 31.7Yes
4417292D structureCHEMBL3393556C16H25N5287.4115 / 21.8Yes
4417302D structureCHEMBL3393557C16H25N5287.4115 / 21.8Yes
17872D structureciproxifanC16H18N2O2270.3323 / 12.5Yes
18052D structureCHEMBL1915051C13H13ClN6O304.7387 / 21.1Yes
22852D structure1-(cyclohexylmethyl)pyrrolidineC11H21N167.2961 / 03.1Yes
24322D structureCHEMBL3236565C14H23N5O277.3726 / 30.8Yes
30232D structureUNII-10521U3EQAC23H31NO3S401.5654 / 04.2Yes
31312D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
33282D structureCHEMBL3220637C11H18N6234.3073 / 30.8Yes
34532D structureCHEMBL2314768C18H21FN6340.4066 / 12.3Yes
36992D structureCHEMBL3220892C17H23N5O313.4053 / 21.7Yes
37282D structureCHEMBL2047444C15H19N3O257.3372 / 22.0Yes
42182D structureCHEMBL202638C12H23N3209.3372 / 22.0Yes
46362D structureCHEMBL1915345C16H18ClN3O303.792 / 12.6Yes
50942D structureCHEMBL260456C20H21ClN4O368.8655 / 03.9Yes
54032D structureCHEMBL3085393C14H18ClN5291.7835 / 22.7Yes
54042D structureCHEMBL435439C14H18ClN5291.7835 / 22.7Yes
55132D structureCHEMBL522019C15H20N6O300.3667 / 10.7Yes
56822D structureAC1L1HUKC29H28ClN3O4518.014 / 25.2No
58662D structureCHEMBL1923030C18H31BrN4S415.4383 / 3N/AN/A
64102D structureCHEMBL3290579C14H17IN6396.2366 / 12.2Yes
5574582D structureCHEMBL377765C18H18ClN3311.8132 / 14.1Yes
4637262D structureCHEMBL3633757C26H24BrNO4494.3855 / 05.4No
72332D structureCHEMBL1258754C19H25N3O2327.4283 / 12.7Yes
73552D structure2,6-Bis(guanidinomethyl)pyridineC9H15N7221.2683 / 4-2.2Yes
73562D structureAC1O3VDWC9H17N7+2223.2841 / 6-2.2No
74552D structureCHEMBL259957C19H21N5O335.4116 / 02.2Yes
76702D structureCHEMBL455133C18H21N5O323.46 / 12.7Yes
78422D structureCHEMBL1078210C17H22N6310.4053 / 32.3Yes
80202D structureCHEMBL1258755C20H27N3O2341.4553 / 13.0Yes
81022D structureCHEMBL1934066C23H31N321.5081 / 06.7No
85022D structureCHEMBL1688939C14H15N5253.3093 / 11.7Yes
105112D structureCHEMBL446896C10H17N5207.2815 / 10.5Yes
105872D structureCHEMBL3290578C14H17BrN6349.2366 / 12.2Yes
107452D structureCHEMBL3287723C25H32O7444.5247 / 25.7No
112472D structureCHEMBL494982C17H21N3O283.3753 / 12.9Yes
115132D structureCHEMBL1257376C26H30FN3O2435.5434 / 04.5Yes
117942D structurecimetidineC10H16N6S252.344 / 30.4Yes
126922D structureCHEMBL153207C10H17N3179.2672 / 21.0Yes
5218412D structureF3277-0121C17H20N4O296.3745 / 03.1Yes
141252D structureCHEMBL1923034C20H28BrN5O2S482.4415 / 3N/AN/A
145252D structure3-[2-(3H-Imidazol-4-yl)-ethyl]-pyridineC10H11N3173.2192 / 11.2Yes
146472D structureCHEMBL1945848C25H28N4O2416.5255 / 03.7Yes
5363762D structureSCHEMBL603807C22H29FN6396.5146 / 24.1Yes
150652D structureCHEMBL494687C14H24N4248.3744 / 13.3Yes
154682D structureCHEMBL2205829C19H19NO3309.3654 / 12.2Yes
157752D structureCHEMBL379447C12H21N3207.3212 / 21.9Yes
160322D structureISOLOXAPINEC18H18ClN3O327.8123 / 03.1Yes
160572D structureCHEMBL2047259C14H15ClN2O2278.7363 / 02.6Yes
161572D structureCHEMBL1090532C14H13ClN4O288.7355 / 12.4Yes
163392D structureSCHEMBL605165C19H25N5323.4445 / 22.8Yes
169302D structure6-(4-methylpiperazin-1-yl)-9H-purineC10H14N6218.2645 / 10.5Yes
174622D structureCHEMBL1951055C20H30N2O3346.4715 / 02.6Yes
177622D structureCID 54584377C17H25N3O6367.4027 / 4N/AN/A
179692D structureCHEMBL3236569C10H17N5207.2815 / 20.4Yes
179892D structureCHEMBL2031471C23H31N3O2381.524 / 03.8Yes
186702D structureCHEMBL3238444C18H26N4O314.4334 / 03.1Yes
188092D structureCHEMBL306077C11H20N4S240.3692 / 31.2Yes
193082D structureCHEMBL492288C15H18IN5395.2485 / 12.4Yes
194672D structureCHEMBL509961C22H22ClN5S423.9636 / 15.3No
198232D structureCHEMBL1916505C12H21N5235.3355 / 21.6Yes
202342D structureCHEMBL3220888C21H30N4O2370.4974 / 22.9Yes
206962D structureCHEMBL591249C21H31ClN6O2S467.0298 / 13.9Yes
207772D structureCHEMBL1077861C9H14N6206.2533 / 30.0Yes
4654562D structureCHEMBL3628052C18H21N7335.4156 / 22.3Yes
217472D structureCHEMBL1914767C14H15N5O269.3086 / 21.5Yes
220362D structureCHEMBL1770975C15H27N5277.4165 / 32.4Yes
224042D structureCHEMBL2013045C23H34N2O4S434.5956 / 03.4Yes
227352D structureCHEMBL1914794C16H19N5OS329.4227 / 22.5Yes
227362D structureCHEMBL1915022C16H19N5OS329.4227 / 22.5Yes
246792D structureSCHEMBL607510C19H21N5319.4125 / 13.0Yes
246912D structureCHEMBL594266C17H22N6O2342.4038 / 3-0.8Yes
247292D structureCHEMBL1935426C23H33NO4S419.585 / 03.7Yes
247332D structureCHEMBL1914771C15H17N5O2299.3347 / 21.5Yes
247672D structureCHEMBL1914543C14H14ClN5O303.756 / 22.0Yes
248292D structureCHEMBL1078746C18H26N6O342.4473 / 42.4Yes
249552D structureCHEMBL3236564C16H25N5287.4115 / 22.0Yes
255802D structureCHEMBL203263C15H20ClN3277.7962 / 23.1Yes
257602D structureCHEMBL452925C18H20ClN5O357.8426 / 13.3Yes
260632D structureS-(-)-LisurideC20H26N4O338.4552 / 22.7Yes
262942D structureCHEMBL600053C18H18FNO283.3463 / 12.5Yes
5223792D structure4-[4-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]morpholineC14H23N5O277.3726 / 01.0Yes
273162D structureCHEMBL1078735C19H23N7349.4423 / 42.5Yes
275072D structureCHEMBL2432063C19H29N271.4481 / 04.7Yes
279192D structureBRN 0805832C13H15ClN4O278.743 / 11.1Yes
279292D structureCHEMBL1915024C16H16F3N5O351.3339 / 22.6Yes
281292D structureCHEMBL1202323C22H28Br2N4S540.3623 / 4N/ANo
283902D structureCHEMBL3124968C20H35N3O2349.5194 / 01.5Yes
285892D structureCHEMBL1079553C13H23N3O2253.3463 / 22.7Yes
285922D structureCHEMBL1079552C13H23N3O2253.3463 / 22.7Yes
290442D structureCHEMBL377572C15H18ClN3275.782 / 22.6Yes
290492D structureCHEMBL214311C15H18ClN3275.782 / 22.6Yes
290502D structureCHEMBL215628C15H18ClN3275.782 / 22.6Yes

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